CAS 844435-10-5

Benzamide, 4-[[5-fluoro-4-(phenylamino)-2-pyrimidinyl]amino]-

Description:

Benzamide, 4-[[5-fluoro-4-(phenylamino)-2-pyrimidinyl]amino]- is a chemical compound characterized by its complex structure, which includes a benzamide moiety and a pyrimidine ring substituted with a fluorine atom and a phenylamino group. This compound typically exhibits properties associated with both aromatic and heterocyclic compounds, such as stability and potential for hydrogen bonding due to the presence of the amide functional group. It is likely to be a solid at room temperature, with moderate solubility in organic solvents. The presence of the fluorine atom can enhance lipophilicity and influence the compound's biological activity, making it of interest in pharmaceutical research, particularly in the development of targeted therapies. The compound's molecular interactions may be influenced by its ability to form hydrogen bonds and engage in π-π stacking due to the aromatic rings. Overall, this compound's unique structure suggests potential applications in medicinal chemistry, particularly in the design of inhibitors or modulators of specific biological targets.

Formula: C₁₇H₁₄FN₅O

Synonyms:

• Benzamide, 4-[[5-fluoro-4-(phenylamino)-2-pyrimidinyl]amino]-

AJI-100

CAS: 844435-10-5

AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).

Formula: C₁₇H₁₄FN₅O

Color and Shape: Solid

Molecular weight: 323.32

Ref: TM-T200052