CAS 84478-72-8

5-amino-2-chloro-4-fluorophenol

Description:

5-Amino-2-chloro-4-fluorophenol is an organic compound characterized by the presence of an amino group (-NH2), a chloro group (-Cl), and a fluoro group (-F) attached to a phenolic ring. This compound typically appears as a solid and is soluble in polar solvents due to the hydroxyl group (-OH) on the phenol, which can engage in hydrogen bonding. The presence of both chlorine and fluorine substituents introduces unique electronic and steric effects, influencing its reactivity and potential applications in various chemical reactions, including nucleophilic substitutions and coupling reactions. The amino group can act as a nucleophile, while the halogen substituents can serve as leaving groups under certain conditions. This compound may be of interest in pharmaceutical chemistry and materials science, particularly in the synthesis of dyes, agrochemicals, or as intermediates in the production of more complex molecules. Safety data should be consulted, as halogenated compounds can exhibit varying degrees of toxicity and environmental impact.

Formula: C₆H₅ClFNO

InChI: InChI=1/C6H5ClFNO/c7-3-1-4(8)5(9)2-6(3)10/h1-2,10H,9H2

InChI key: InChIKey=AFZLCOLNTRPSIF-UHFFFAOYSA-N

SMILES: ClC1=C(O)C=C(N)C(F)=C1

Synonyms:

• 2-Chloro-4-fluoro-5-aminophenol
• 2-Fluoro-4-chloro-5-hydroxyaniline
• 4-Chloro-2-fluoro-5-hydroxyaniline
• 5-Amino-2-Chloro-4-Fluoro-Phenol
• Phenol, 5-amino-2-chloro-4-fluoro-
• 5-Amino-2-chloro-4-fluorophenol
• 5-amino-2-chloro-4-fluoro-phenol ISO 9001：2015 REACH

5-Amino-2-chloro-4-fluorophenol

CAS: 84478-72-8

Formula: C₆H₅ClFNO

Purity: 97%

Color and Shape: Solid

Molecular weight: 161.5614

Ref: IN-DA004S2J

5-Amino-2-chloro-4-fluorophenol

CAS: 84478-72-8

5-Amino-2-chloro-4-fluorophenol

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 161.56g/mol

Ref: 54-PC10135

5-Amino-2-chloro-4-fluorophenol

CAS: 84478-72-8

Formula: C₆H₅ClFNO

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 161.56

Ref: 10-F010724

5-Amino-2-chloro-4-fluorophenol

Controlled Product

CAS: 84478-72-8

Applications 5-Amino-2-chloro-4-fluorophenol is a reagent involved in the design and structure of potent vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors.
References Hennequin, L. F., et al.: J. Med. Chem., 42, 5369-5389 (1999);

Formula: C₆H₅ClFNO

Color and Shape: Neat

Molecular weight: 161.56

Ref: TR-A595495