CAS 845273-93-0

Sevelamer carbonate

Description:

Sevelamer carbonate is a polymeric compound primarily used as a phosphate binder in patients with chronic kidney disease who are on dialysis. It is a non-absorbed, non-calcium-based agent that helps to reduce serum phosphate levels by binding dietary phosphate in the gastrointestinal tract, preventing its absorption. The substance is characterized by its high molecular weight and a complex structure that includes amine and carboxyl functional groups, which contribute to its binding properties. Sevelamer carbonate is typically administered in tablet or powder form and is known for its ability to maintain a neutral pH in the gastrointestinal tract, which can be beneficial for patients with metabolic acidosis. Additionally, it has been shown to have a favorable safety profile, with common side effects including gastrointestinal disturbances. The compound is also noted for its potential to positively influence lipid profiles and may have additional benefits beyond phosphate control. Overall, sevelamer carbonate plays a crucial role in managing mineral and bone disorders in patients with renal impairment.

Formula: (C₃H₇N·C₃H₅ClO)x·xCH₂O₃

InChI: InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)

InChI key: InChIKey=PADGNZFOVSZIKZ-UHFFFAOYSA-N

SMILES: C(=O)(O)O.C(CN)=C.C(Cl)C1CO1

Synonyms:

• 2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate
• Carbonic acid, compd. with (chloromethyl)oxirane polymer with 2-propen-1-amine
• Carbonic acid, compd. with 2-(chloromethyl)oxirane polymer with 2-propen-1-amine
• Genz 644470
• Gt 335-012
• Renvela
• Sevelamer carbonate

Sevelamer Carbonate

CAS: 845273-93-0

Polysulfides, polysulfones & oth products spec in note 3, chapter 39, except elastomeric

Formula: (C₃H₇N)ab(C₉H₁₈N₂O)cn·xH₂CO₃

Color and Shape: White Pale Yellow Powder

Ref: 45-1612459

Sevelamer (carbonate)

CAS: 845273-93-0

Formula: C₂₅H₆₆N₄O

Purity: %

Color and Shape: Solid

Molecular weight: 438.8177

Ref: IN-DA00G27H

Sevelamer Carbonate

CAS: 845273-93-0

Color and Shape: Pale Yellow Solid

Ref: 4Z-S-222

Sevelamer Carbonate

CAS: 845273-93-0

Sevelamer carbonate, a non-absorbed polymer, binds phosphate with carbonate instead of chloride.

Formula: (C₃H₇N·C₃H₅ClO)x·xCH₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 211.64

Ref: TM-T6666

Sevelamer Carbonate, Technical Grade

CAS: 845273-93-0

Formula: C₃H₇N·C₃H₅ClO·CH₂O₃

Color and Shape: Off White Solid

Molecular weight: 211.64

Ref: TR-S039370

Sevelamer carbonate

CAS: 845273-93-0

Sevelamer carbonate is a drug that belongs to the class of non-absorbable phosphate binders. It is used in the treatment of chronic hyperphosphatemia, which is a condition marked by abnormally high levels of phosphates in the blood. Sevelamer carbonate works by binding to dietary phosphate and other phosphates in the body, preventing them from being absorbed into the bloodstream. This prevents an increase in serum phosphate levels. Sevelamer carbonate has been shown to be effective against bowel disease and experimental models for heart disease. It also has been shown to have an effect on infections caused by infectious diseases such as HIV infection, hepatitis C virus infection, or bacterial infection, as well as autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus.

Color and Shape: White Powder

Ref: 3D-FS137481