CAS 845533-86-0

Bedaquiline fumarate

Description:

Bedaquiline fumarate is a novel anti-tuberculosis medication primarily used in the treatment of multidrug-resistant tuberculosis (MDR-TB). It is a diarylquinoline compound that selectively inhibits the ATP synthase enzyme in Mycobacterium tuberculosis, disrupting the bacterium's energy production and leading to its death. The fumarate salt form enhances its solubility and stability. Bedaquiline is characterized by its long half-life, allowing for once-daily dosing, which improves patient adherence to treatment regimens. Common side effects may include nausea, headache, and potential cardiovascular effects, such as QT interval prolongation, necessitating monitoring during therapy. It is typically used in combination with other anti-TB agents to prevent the development of resistance. Due to its specific mechanism of action and the emergence of drug-resistant strains of tuberculosis, Bedaquiline represents a significant advancement in the fight against this global health challenge. Its approval by regulatory agencies has provided a new therapeutic option for patients with limited treatment alternatives.

Formula: C₃₂H₃₁BrN₂O₂·C₄H₄O₄

SMILES: [C@]([C@@H](C=1C(OC)=NC2=C(C1)C=C(Br)C=C2)C3=CC=CC=C3)(CCN(C)C)(O)C=4C5=C(C=CC4)C=CC=C5.C(=C/C(O)=O)\C(O)=O

Synonyms:

• (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol,(E)-but-2-enedioic acid
• (4R,12aS)-7-(benzyloxy)-9-bromo-4-methyl-3,4-dihydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-6,8(12H,12aH)-dione
• 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)-, (2E)-2-butenedioate (1:1) (salt)
• Bedaquiline fumarate
• R 403323
• Sirturo

(1R,2S)-1-(6-Bromo-2-Methoxyquinolin-3-Yl)-4-(Dimethylamino)-2-(Naphthalen-1-Yl)-1-Phenylbutan-2-Ol Fumarate

CAS: 845533-86-0

(1R,2S)-1-(6-Bromo-2-Methoxyquinolin-3-Yl)-4-(Dimethylamino)-2-(Naphthalen-1-Yl)-1-Phenylbutan-2-Ol Fumarate

Purity: 99%

Molecular weight: 671.58g/mol

Ref: 54-OR1025438

Bedaquiline fumarate

CAS: 845533-86-0

Formula: C₃₂H₃₁BrN₂O₂·C₄H₄O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 671.58

Ref: 7W-GA1399

Bedaquiline fumarate

CAS: 845533-86-0

Bedaquiline fumarate

Purity: ≥98%

Molecular weight: 671.59g/mol

Ref: 54-BUP15596

Bedaquiline Fumarate

CAS: 845533-86-0

Formula: C₃₂H₃₁BrN₂O₂·C₄H₄O₄

Molecular weight: 555.52 116.07

Ref: 4Z-B-101027

Bedaquiline fumarate

CAS: 845533-86-0

Bedaquiline, a diarylquinoline antibiotic, targets ATP synthase in Mycobacterium tuberculosis.

Formula: C₃₆H₃₅BrN₂O₆

Purity: 98.88% - 99.93%

Color and Shape: Solid

Molecular weight: 671.59

Ref: TM-T21023

Bedaquiline fumarate

CAS: 845533-86-0

Bedaquiline fumarate is the salt form of bedaquiline, a diarylquinoline molecule with an ATP synthetase inhibitory activity. Bedaquiline fumarate is an FDA-approved drug for the oral treatment of multidrug-resistant tuberculosis. Bedaquiline fumarate acts by inhibiting the activity of the ATP synthetase in the pathogenic bacterium Mycobacterium tuberculosis, even in the case of multiple antibiotic resistant strains.

Formula: C₃₂H₃₁BrN₂O₂•C₄H₄O₄

Purity: Min. 97 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 671.58 g/mol

Ref: 3D-FB71553