CAS 845647-80-5

BF 227

Controlled Product

CAS: 845647-80-5

Formula: C₁₆H₁₆FN₃O₂S

Color and Shape: Neat

Molecular weight: 791.934

Ref: TR-B360000

BF 227

CAS: 845647-80-5

BF 227 is a diagnostic compound, which is a synthetic amyloid-imaging agent used in positron emission tomography (PET) scans. It is derived from chemical synthesis, specifically designed to bind selectively to amyloid-beta plaques, a hallmark of Alzheimer's disease pathology.

The mode of action of BF 227 involves its ability to cross the blood-brain barrier and selectively bind to amyloid-beta deposits within the brain. Once administered, this compound exhibits high affinity to these plaques, allowing it to serve as a contrast agent in PET imaging. This binding is crucial as it illuminates areas of plaque accumulation, providing a visual representation of amyloid load and aiding in the diagnosis of Alzheimer’s.

BF 227 is primarily used in research and clinical settings to enable the non-invasive quantification of amyloid plaques in living patients. Its application is pivotal for early detection and differentiation of Alzheimer's disease from other forms of dementia. By providing insights into the extent of amyloid deposition, BF 227 assists in the evaluation of disease progression and the effectiveness of therapeutic interventions, thereby contributing significantly to Alzheimer's research and patient management.

Formula: C₁₆H₁₆FN₃O₂S

Purity: Min. 95%

Molecular weight: 333.4 g/mol

Ref: 3D-VIB64780

BF 227

CAS: 845647-80-5

BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].

Formula: C₁₆H₁₆FN₃O₂S

Color and Shape: Solid

Molecular weight: 333.38

Ref: TM-T10530