CAS 84625-61-6: Itraconazole

Description: Itraconazole is a triazole antifungal agent primarily used to treat various fungal infections, including those caused by dermatophytes, yeasts, and certain molds. It functions by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and function. Itraconazole is characterized by its relatively low solubility in water but is more soluble in organic solvents, which influences its bioavailability. The compound has a molecular formula of C35H38Cl2N8O4S and features a complex structure that includes a triazole ring. It is typically administered orally or intravenously, with its pharmacokinetics influenced by factors such as food intake and pH levels. Itraconazole is known for its broad spectrum of activity against various fungi, but it may also interact with other medications due to its effects on liver enzymes. Common side effects can include gastrointestinal disturbances, liver enzyme elevations, and potential cardiovascular effects, necessitating monitoring during treatment.

Formula: C₃₅H₃₈Cl₂N₈O₄

InChI: InChI=1/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/s2

InChI key: InChIKey=VHVPQPYKVGDNFY-WGEGMAFPNA-N

SMILES: O=C1N(N=CN1C2=CC=C(C=C2)N3CCN(C4=CC=C(OCC5OC(OC5)(C6=CC=C(Cl)C=C6Cl)CN7N=CN=C7)C=C4)CC3)C(C)CC

Synonyms:

• 2-Butan-2-Yl-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1,2,4-Triazol-1-Yl Methyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-1,2,4-Triazol-3-One
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
• Candistat
• Canditral
• Cladosal 100
• Fungitraxx
• Itrac
• Itraconozole
• Itralek
• Itrizole
• Oriconazole
• Orungal
• Orungamin
• Pur 1900
• R 51211
• SUBA Itraconazole
• Sempera
• Spherazole CR
• Spherazole IR
• Sporal
• Sporamelt
• Sporanox
• Sporanox IV
• Sporonox
• Traconal
• Triasporin
• cis-Itraconazole
• rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
• Itraconazole

Itraconazole

CAS: 84625-61-6

Applications Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a …

• Formula: C₃₅H₃₈Cl₂N₈O₄
• Color and Shape: White To Off-White
• Molecular weight: 705.63

Itraconazole

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the …

• Formula: C₃₅H₃₈Cl₂N₈O₄
• Purity: Min. 98.5 Area-%
• Color and Shape: White Powder
• Molecular weight: 705.63 g/mol

Itraconazole - Bio-X ™

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the …

• Formula: C₃₅H₃₈Cl₂N₈O₄
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 705.63 g/mol