CAS 846589-98-8

Lorcaserin hydrochloride

Description:

Lorcaserin hydrochloride is a selective serotonin 2C receptor agonist primarily used as an anti-obesity medication. It is characterized by its ability to promote satiety and reduce appetite, making it effective for weight management in individuals with obesity or overweight conditions. The compound has a molecular formula that includes carbon, hydrogen, nitrogen, oxygen, and chlorine, reflecting its complex structure. Lorcaserin hydrochloride is typically administered orally and is known for its relatively favorable safety profile compared to other weight-loss medications. However, it may still present side effects, including headaches, dizziness, and fatigue. The substance has been studied for its potential cardiovascular effects, and its use was associated with a modest weight loss in clinical trials. Due to concerns regarding potential risks, including the development of tumors in animal studies, Lorcaserin was withdrawn from the market in early 2020. Overall, Lorcaserin hydrochloride exemplifies the challenges and considerations in pharmacotherapy for obesity management.

Formula: C₁₁H₁₄ClN·ClH

InChI: InChI=1S/C11H14ClN.ClH/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9;/h2-3,6,8,13H,4-5,7H2,1H3;1H/t8-;/m0./s1

InChI key: InChIKey=ITIHHRMYZPNGRC-QRPNPIFTSA-N

SMILES: C[C@@H]1C=2C(=CC=C(Cl)C2)CCNC1.Cl

Synonyms:

• (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride
• (R)-1H-3-Benzazepine,8-Chloro-2,3,4,5-Tetrahydro-1-Methyl-,Hydrochloride
• (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
• (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride
• (R)-Lorcaserin hydrochloride
• 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-, hydrochloride (1:1), (1R)-
• 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-, hydrochloride, (1R)-
• Apd 356
• Lorcaserin HCl
• Unii-0Qjf08Gdpe
• Lorcaserin hydrochloride

Lorcaserin HCl

CAS: 846589-98-8

Formula: C₁₁H₁₄ClN·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 195.69 36.46

Ref: 4Z-L-095001

Lorcaserin Hydrochloride (>50% ee)

Controlled Product

CAS: 846589-98-8

Applications A novel selective 5-HT2C-receptor agonist for the treatment of obesity.
References Pauli, M., et al.: Formulary, 45, 180 (2010), Ioannides-Demos, L.L., et al.: J. Obesity, 18, 179674 (2011),

Formula: C₁₁H₁₄ClN·ClH

Color and Shape: Neat

Molecular weight: 232.15

Ref: TR-L469890

Lorcaserin Hydrochloride-d4

Controlled Product

CAS: 846589-98-8

Stability Hygroscopic
Applications Lorcaserin hydrochloride is a highly selective 5-HT2C receptor agonist developed for the treatment of obesity.
References Wang, Y., et al.: Drugs. Future., 32, 766 (2007);

Formula: C₁₁H₁₁D₄Cl₂N

Color and Shape: Neat

Molecular weight: 236.17

Ref: TR-L469897