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CAS 847353-30-4

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Arbaclofen placarbil

Description:
Arbaclofen placarbil is a chemical compound that acts as a prodrug of baclofen, a muscle relaxant and antispastic agent. It is designed to enhance the pharmacokinetic properties of baclofen, improving its absorption and bioavailability. The substance primarily functions as a GABA-B receptor agonist, which plays a crucial role in the central nervous system by inhibiting neurotransmitter release and reducing neuronal excitability. Arbaclofen placarbil is characterized by its ability to provide therapeutic effects in conditions such as spasticity and certain types of neuropathic pain. Its chemical structure includes a modified baclofen backbone, which contributes to its improved solubility and absorption profile compared to traditional baclofen. The compound has been investigated for its potential benefits in treating various neurological disorders, although its clinical use may be subject to regulatory approvals and ongoing research. As with any pharmaceutical agent, understanding its pharmacodynamics, pharmacokinetics, and potential side effects is essential for safe and effective use.
Formula:C19H26ClNO6
InChI:InChI=1S/C19H26ClNO6/c1-11(2)17(24)26-18(12(3)4)27-19(25)21-10-14(9-16(22)23)13-5-7-15(20)8-6-13/h5-8,11-12,14,18H,9-10H2,1-4H3,(H,21,25)(H,22,23)/t14-,18-/m0/s1
InChI key:InChIKey=JXTAALBWJQJLGN-KSSFIOAISA-N
SMILES:[C@@H](CNC(O[C@H](OC(C(C)C)=O)C(C)C)=O)(CC(O)=O)C1=CC=C(Cl)C=C1
Synonyms:
  • (3R)-4-[[(1S)-2-Methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino]-3-(4-chlorophenyl)butanoic acid
  • Benzenepropanoic acid, 4-chloro-β-[[[[(1S)-2-methyl-1-(2-methyl-1-oxopropoxy)propoxy]carbonyl]amino]methyl]-, (βR)-
  • XP 19986
  • (βR)-4-Chloro-β-[[[[(1S)-2-methyl-1-(2-methyl-1-oxopropoxy)propoxy]carbonyl]amino]methyl]benzenepropanoic acid
  • Arbaclofen placarbil
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