CAS 847499-27-8

Delanzomib

Description:

Delanzomib, with the CAS number 847499-27-8, is a small molecule inhibitor that primarily targets the proteasome, a cellular complex responsible for degrading ubiquitinated proteins. This compound is classified as a proteasome inhibitor and has been investigated for its potential therapeutic applications, particularly in the treatment of various cancers, including multiple myeloma and solid tumors. Delanzomib exhibits a unique mechanism of action by disrupting protein homeostasis within cancer cells, leading to apoptosis and inhibiting tumor growth. Its chemical structure features a specific arrangement of functional groups that contribute to its biological activity. In preclinical studies, Delanzomib has shown promise in overcoming resistance to other therapies, making it a candidate for combination treatments. However, like many investigational drugs, its safety and efficacy profiles are still under evaluation in clinical trials. Overall, Delanzomib represents a significant area of research in the field of oncology, particularly in the development of targeted therapies for malignancies.

Formula: C₂₁H₂₈BN₃O₅

InChI: InChI=1S/C21H28BN3O5/c1-13(2)12-18(22(29)30)24-21(28)19(14(3)26)25-20(27)17-11-7-10-16(23-17)15-8-5-4-6-9-15/h4-11,13-14,18-19,26,29-30H,12H2,1-3H3,(H,24,28)(H,25,27)/t14-,18+,19+/m1/s1

InChI key: InChIKey=SJFBTAPEPRWNKH-CCKFTAQKSA-N

SMILES: C(N[C@H](C(N[C@@H](CC(C)C)B(O)O)=O)[C@@H](C)O)(=O)C1=NC(=CC=C1)C2=CC=CC=C2

Synonyms:

• [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid
• B-[(1R)-1-[[(2S,3R)-3-Hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]boronic acid
• Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]-
• Boronic acid, B-[(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]-
• CEP 18770

[(1R)-1-[(2S,3R)-3-hydroxy-2-[(6-phenylpyridin-2-yl)formamido]butanamido]-3-methylbutyl]boronic acid

CAS: 847499-27-8

Formula: C₂₁H₂₈BN₃O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 413.2751

Ref: IN-DA003AFZ

Delanzomib

CAS: 847499-27-8

Delanzomib

Purity: ≥95%

Molecular weight: 413.28g/mol

Ref: 54-BUP09103

Delanzomib [CEP-18770]

CAS: 847499-27-8

Ref: 7W-GW5337

Delanzomib

CAS: 847499-27-8

Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.

Formula: C₂₁H₂₈BN₃O₅

Purity: 95.52% - 99.46%

Color and Shape: Solid

Molecular weight: 413.28

Ref: TM-T6027

[(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid

CAS: 847499-27-8

Purity: ≥97%

Molecular weight: 413.2799988

Ref: 10-F862566

Delanzomib

Controlled Product

CAS: 847499-27-8

Stability Hygroscopic
Applications Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-κB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.
References Piva, R. et al.: Blood, 111, 2765 (2008); Sanchez, E. et al.: Br. J. Haematol., 148, 569 (2010);

Formula: C₂₁H₂₈BN₃O₅

Color and Shape: Neat

Molecular weight: 413.28

Ref: TR-D230710