CAS 848074-10-2

Palonosetron Impurity 19

CAS: 848074-10-2

Formula: C₁₉H₂₂N₂O₂

Molecular weight: 310.40

Ref: 4Z-P-5330

6-Oxo-(S,S)-Palonosetron (~90%)

Controlled Product

CAS: 848074-10-2

Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

Formula: C₁₉H₂₂N₂O₂

Purity: ~90%

Color and Shape: Neat

Molecular weight: 310.39

Ref: TR-O858568

6-Oxo-(S,S)-palonosetron

CAS: 848074-10-2

Palonosetron is a 5-HT3 receptor antagonist that is used to treat nausea and vomiting caused by chemotherapy. It has a high affinity for the 5-HT3 receptor, but it does not inhibit other serotonin receptors. 6-Oxo-(S,S)-palonosetron is an inhibitor of the enzyme protein interactions that are responsible for the activation of the 5-HT3 receptor. It also binds to the Ligand binding site of the 5-HT3 receptor and blocks signaling to downstream ion channels. Palonosetron has been shown to be an activator of the 5-HT3 receptor in vitro and in vivo. This drug is water soluble with a purity level over 99%. Palonosetron can be used as a research tool or as an antibody reagent.

Formula: C₁₉H₂₂N₂O₂

Purity: Min. 95%

Molecular weight: 310.4 g/mol

Ref: 3D-YIB07410

Palonosetron Impurity 19

CAS: 848074-10-2

Formula: C₁₉H₂₂N₂O₂

Molecular weight: 310.4

Ref: ST-EA-CP-P14027