CAS 84845-57-8
:Ritipenem
Description:
Ritipenem is a synthetic beta-lactam antibiotic belonging to the carbapenem class, characterized by its broad-spectrum antibacterial activity. It is effective against a wide range of Gram-positive and Gram-negative bacteria, including many strains resistant to other antibiotics. Ritipenem works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Its structure features a beta-lactam ring, which is crucial for its antibacterial properties, and a thiazolidine ring that enhances its stability against beta-lactamases, enzymes produced by some bacteria to confer resistance. Ritipenem is typically administered intravenously and is used in the treatment of serious infections, particularly those caused by multidrug-resistant organisms. The pharmacokinetics of ritipenem include rapid distribution in body tissues, with a relatively short half-life, necessitating careful dosing. As with other antibiotics, the potential for adverse effects exists, including allergic reactions and gastrointestinal disturbances. Overall, ritipenem represents an important option in the arsenal against resistant bacterial infections, although its use is often guided by susceptibility testing to ensure effectiveness.
Formula:C10H12N2O6S
InChI:InChI=1S/C10H12N2O6S/c1-3(13)5-7(14)12-6(9(15)16)4(19-8(5)12)2-18-10(11)17/h3,5,8,13H,2H2,1H3,(H2,11,17)(H,15,16)/t3-,5+,8-/m1/s1
InChI key:InChIKey=IKQNRQOUOZJHTR-UWBRJAPDSA-N
SMILES:C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])(SC1COC(N)=O)[H]
Synonyms:- (5R,6S)-3-[(carbamoyloxy)methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- (5R,6S)-3-[[(Aminocarbonyl)oxy]methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- (5R,6S)-6-((1R)-1-Hydroxyethyl)-3-(hydroxymethyl)-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-carbamate
- 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-
- 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-6-(1-hydroxyethyl)-7-oxo-, [5R-[5α,6α(R*)]]-
- 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-, (5R,6S)-
- Ritipenem [INN]
- Unii-D4Sl77931L
- Ritipenem
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Found 2 products.
Ritipenem
CAS:Ritipenem is a cationic peptide antibiotic with an antimicrobial spectrum similar to that of the penem group. It binds to the cytoplasmic membrane of Gram-negative bacteria, forming ion channels and leading to an increase in membrane permeability and cell death. Ritipenem has been shown to inhibit protein interactions, ligand binding and receptor activation by other agonists, as well as having affinity for a wide range of peptides. The purity of this compound is high, with no detectable traces of contaminants such as endotoxins or proteases. Ritipenem also has been shown to have antibacterial activity against Mycobacterium tuberculosis and other mycobacteria.
Formula:C10H12N2O6SPurity:Min. 95%Molecular weight:288.28 g/mol
