CAS 848942-61-0

Sapitinib

Description:

Sapitinib is a small molecule inhibitor primarily known for its role as a targeted therapy in cancer treatment, particularly in cases involving mutations in the epidermal growth factor receptor (EGFR). It is classified as a tyrosine kinase inhibitor, which means it interferes with the signaling pathways that promote cell proliferation and survival, thereby inhibiting tumor growth. The chemical structure of Sapitinib includes a quinazoline core, which is common among many EGFR inhibitors. Its mechanism of action involves binding to the ATP-binding site of the EGFR, preventing its activation and subsequent downstream signaling. Sapitinib has been investigated for its efficacy in various malignancies, including non-small cell lung cancer (NSCLC). In terms of pharmacokinetics, it exhibits moderate oral bioavailability and is metabolized primarily by the liver. The substance's safety profile includes potential side effects typical of targeted therapies, such as skin rash and gastrointestinal disturbances. Overall, Sapitinib represents a significant advancement in personalized medicine, particularly for patients with specific genetic alterations in their tumors.

Formula: C₂₃H₂₅ClFN₅O₃

InChI: InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29)

InChI key: InChIKey=DFJSJLGUIXFDJP-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OC)C(OC3CCN(CC(NC)=O)CC3)=C2)N=CN1)C4=C(F)C(Cl)=CC=C4

Synonyms:

• 1-Piperidineacetamide, 4-[[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-
• 2-[4-[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide
• 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline
• 4-[[4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-1-piperidineacetamide
• Azd-8931
• Azd8931
• Sapatinib
• Sapitinib

AZD8931

CAS: 848942-61-0

Formula: C₂₃H₂₅ClFN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 473.9277

Ref: IN-DA00G3RJ

2-(4-((4-((3-Chloro-2-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Yl)Oxy)Piperidin-1-Yl)-N-Methylacetamide

CAS: 848942-61-0

2-(4-((4-((3-Chloro-2-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Yl)Oxy)Piperidin-1-Yl)-N-Methylacetamide

Purity: 98%

Molecular weight: 473.93g/mol

Ref: 54-PC108701

Sapitinib

CAS: 848942-61-0

Sapitinib

Purity: ≥98%

Molecular weight: 473.93g/mol

Ref: 54-BUP05871

Sapitinib

CAS: 848942-61-0

Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or

Formula: C₂₃H₂₅ClFN₅O₃

Purity: 98.89% - 99.83%

Color and Shape: Solid

Molecular weight: 473.93

Ref: TM-T6092

Sapatinib

Controlled Product

CAS: 848942-61-0

Formula: C₂₃H₂₅ClFN₅O₃

Color and Shape: Neat

Molecular weight: 473.928

Ref: TR-S159275