CAS 84903-78-6

O-Desmethyldiltiazem

Description:

O-Desmethyldiltiazem is a chemical compound that serves as a metabolite of diltiazem, a calcium channel blocker commonly used in the treatment of hypertension and angina. This substance is characterized by its molecular structure, which includes a benzothiazepine core, contributing to its pharmacological activity. O-Desmethyldiltiazem exhibits properties typical of calcium channel blockers, such as the ability to inhibit calcium influx into cardiac and smooth muscle cells, leading to vasodilation and reduced heart rate. The compound is typically found in a crystalline form and is soluble in organic solvents, with limited solubility in water. Its pharmacokinetic profile is influenced by factors such as metabolism and excretion, which are important for understanding its therapeutic effects and potential side effects. As a metabolite, O-Desmethyldiltiazem may also play a role in the overall efficacy and safety profile of diltiazem, making it a relevant subject of study in pharmacology and medicinal chemistry.

Formula: C₂₁H₂₄N₂O₄S

Synonyms:

• (2S,3S)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one
• O-Desmethyldiltiazem
• 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-hydroxyphenyl)-, (2S,3S)-
• [5-[2-(dimethylamino)ethyl]-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
• DiltiazeM IMpurity C HCl (O-DesMethyl DiltiazeM HCl)
• [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate