CAS 849217-64-7

Foretinib

Description:

Foretinib is a small molecule inhibitor primarily targeting receptor tyrosine kinases, particularly MET and VEGFR2, which are involved in various cellular processes such as proliferation, survival, and angiogenesis. It is classified as an experimental anticancer agent and has been investigated for its potential in treating various malignancies, including renal cell carcinoma and other solid tumors. Foretinib exhibits a unique chemical structure that allows it to interfere with the signaling pathways associated with tumor growth and metastasis. The compound is typically administered orally and has been evaluated in clinical trials for its efficacy and safety profile. Its mechanism of action involves blocking the phosphorylation of specific tyrosine residues, thereby inhibiting downstream signaling cascades that promote cancer cell survival and proliferation. As with many targeted therapies, the effectiveness of Foretinib may vary based on the genetic and molecular characteristics of the tumor, highlighting the importance of personalized medicine in oncology.

Formula: C₃₄H₃₄F₂N₄O₆

InChI: InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)

InChI key: InChIKey=CXQHYVUVSFXTMY-UHFFFAOYSA-N

SMILES: C(NC1=CC(F)=C(OC=2C3=C(C=C(OCCCN4CCOCC4)C(OC)=C3)N=CC2)C=C1)(=O)C5(C(NC6=CC=C(F)C=C6)=O)CC5

Synonyms:

• 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N′-(4-fluorophenyl)-
• 1-N′-[3-Fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• Exel 2880
• Foretinib
• Gsk 1363089
• Gsk 1363089G
• N-[3-Fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
• Xl 880

N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

CAS: 849217-64-7

Formula: C₃₄H₃₄F₂N₄O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 632.6538

Ref: IN-DA0038E4

N-(3-Fluoro-4-((6-Methoxy-7-(3-Morpholinopropoxy)Quinolin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide

CAS: 849217-64-7

N-(3-Fluoro-4-((6-Methoxy-7-(3-Morpholinopropoxy)Quinolin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide

Formula: C₃₄H₃₄F₂N₄O₆

Purity: 98%

Molecular weight: 632.65

Ref: 54-PC108489

Foretinib

CAS: 849217-64-7

Foretinib

Formula: C₃₄H₃₄F₂N₄O₆

Purity: ≥98%

Molecular weight: 632.65

Ref: 54-BUP13090

Foretinib

CAS: 849217-64-7

Formula: C₃₄H₃₄F₂N₄O₆

Molecular weight: 632.66

Ref: 4Z-F-186001

Foretinib

CAS: 849217-64-7

N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Formula: C₃₄H₃₄F₂N₄O₆

Purity: 98%

Molecular weight: 632.65

Ref: IN-DG210543

Foretinib

CAS: 849217-64-7

Formula: C₃₄H₃₄F₂N₄O₆

Molecular weight: 632.65

Ref: 7W-GP7709

Foretinib

CAS: 849217-64-7

Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.

Formula: C₃₄H₃₄F₂N₄O₆

Purity: 98.07% - 99.68%

Color and Shape: Solid

Molecular weight: 632.65

Ref: TM-T3113

Foretinib

CAS: 849217-64-7

Ref: BE-RMCF174000

Foretinib

Controlled Product

CAS: 849217-64-7

Applications Foretinib (GSK1363089) is an ATP-competitive inhibitor of hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF) Receptor Tyrosine Kinases.
References Qian, F., et al.: Cancer Res., 69, 8009 (2009); Eder, J., et al.: Clin. Cancer Res., 16, 3507 (2010)

Formula: C₃₄H₃₄F₂N₄O₆

Color and Shape: Neat

Molecular weight: 632.65

Ref: TR-F691200

Foretinib

CAS: 849217-64-7

Inhibits MET, VEGFR2, Ron, AXL, Tie-2, Flt-1, Flt-3 and Flt-4 tyrosine kinases

Formula: C₃₄H₃₄F₂N₄O₆

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 632.24464

Ref: 3D-FF42412