CAS 849217-68-1

Cabozantinib

Description:

Cabozantinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of various cancers, including medullary thyroid carcinoma and renal cell carcinoma. It functions by inhibiting multiple receptor tyrosine kinases, including MET, VEGFR, and AXL, which are involved in tumor growth, angiogenesis, and metastasis. The chemical formula of cabozantinib is C19H19N7O2S, and it has a molecular weight of approximately 421.5 g/mol. This compound is characterized by its complex structure, which includes a pyridine ring and a sulfonamide group, contributing to its pharmacological activity. Cabozantinib is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its efficacy is often evaluated in clinical settings, where it has shown promise in improving progression-free survival in patients with advanced cancers. However, like many targeted therapies, it may also be associated with a range of side effects, necessitating careful monitoring during treatment.

Formula: C₂₈H₂₄FN₃O₅

InChI: InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)

InChI key: InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N

SMILES: C(NC1=CC=C(OC=2C3=C(C=C(OC)C(OC)=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4

Synonyms:

• 1-N-[4-(6,7-Dimethoxyquinolin-4-yl)oxyphenyl]-1-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• Bms-907351
• Cabometyx
• Cabozantinib
• N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
• Xl 184
• Xl184
• 1,1-Cyclopropanedicarboxamide, N′-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-
• 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-(4-fluorophenyl)-
• 1,1-cyclopropanedicarboxamide, n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-

Cabozantinib

CAS: 849217-68-1

Cabozantinib

Purity: 98%

Molecular weight: 501.51g/mol

Ref: 54-PC109085

Cabozantinib

CAS: 849217-68-1

Cabozantinib

Purity: ≥98%

Molecular weight: 501.51g/mol

Ref: 54-BUP15501

Cabozantinib

CAS: 849217-68-1

Formula: C₂₈H₂₄FN₃O₅

Color and Shape: White To Off-White Solid

Molecular weight: 501.51

Ref: 4Z-C-284001

Cabozantinib

CAS: 849217-68-1

Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).

Formula: C₂₈H₂₄FN₃O₅

Purity: 99.68% - 99.88%

Color and Shape: Solid

Molecular weight: 501.51

Ref: TM-T2586

Cabozantinib

CAS: 849217-68-1

Ref: 7W-GW6378

XL184

Controlled Product

CAS: 849217-68-1

Formula: C₂₈H₂₄FN₃O₅

Color and Shape: White To Off-White

Molecular weight: 501.51

Ref: TR-X745500

XL184

CAS: 849217-68-1

Pan-tyrosine kinase inhibitor (VEGFR2, c-MET, RET, KIT); anti-neoplastic

Formula: C₂₈H₂₄FN₃O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 501.51 g/mol

Ref: 3D-FD59688