CAS 849658-87-3

Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-[[[5-methyl-4-[4-(1-methylethyl)phenyl]-2-thiazolyl]amino]carbonyl]-, (1R,2S,3R,4S)-rel-

Description:

Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-[[[5-methyl-4-[4-(1-methylethyl)phenyl]-2-thiazolyl]amino]carbonyl]-, (1R,2S,3R,4S)-rel- is a complex organic compound characterized by its bicyclic structure, which consists of a bicyclo[2.2.1]heptane framework. This compound features a carboxylic acid functional group, which contributes to its acidity and reactivity. The presence of a thiazole ring and an aromatic phenyl group with an isopropyl substituent indicates potential for various interactions, including hydrogen bonding and π-π stacking. The stereochemistry is specified by the (1R,2S,3R,4S)- configuration, which suggests specific spatial arrangements of the substituents that can influence the compound's biological activity and physical properties. This compound may exhibit interesting pharmacological properties due to its structural complexity, making it a candidate for further research in medicinal chemistry. Its CAS number, 849658-87-3, allows for precise identification in chemical databases and literature.

Formula: C₂₂H₂₆N₂O₃S

Synonyms:

• Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-[[[5-methyl-4-[4-(1-methylethyl)phenyl]-2-thiazolyl]amino]carbonyl]-, (1R,2S,3R,4S)-rel-

PKZ18

CAS: 849658-87-3

PKZ18 is an antibiotic that inhibits bacterial growth with a MIC value of 32-64 μg/mL against most Gram-positive bacteria. It suppresses the in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria, directly reducing T-box transcription readthrough of associated genes. It prevents codon-anticodon pairing necessary for tRNA binding and is less likely to induce resistance.

Formula: C₂₂H₂₆N₂O₃S

Color and Shape: Solid

Molecular weight: 398.518

Ref: TM-T204863