CAS 85-31-4

Thioguanosine

Description:

Thioguanosine is a nucleoside analog that features a guanine base linked to a ribose sugar, with a sulfur atom replacing the oxygen in the ribose moiety. This modification imparts unique chemical properties to thioguanosine, making it an important compound in biochemical research and therapeutic applications. It is known to participate in various biochemical pathways, particularly in the context of nucleic acid metabolism and cellular signaling. Thioguanosine can be phosphorylated to form thioguanosine triphosphate (TGTP), which can then be incorporated into RNA, potentially affecting RNA stability and function. The compound exhibits antimetabolite properties, which can interfere with DNA and RNA synthesis, making it of interest in cancer treatment and other diseases where cell proliferation is a concern. Additionally, thioguanosine's structural similarity to natural nucleosides allows it to mimic their behavior in biological systems, providing insights into nucleic acid interactions and functions. Its CAS number, 85-31-4, is a unique identifier that facilitates its recognition in chemical databases and literature.

Formula: C₁₀H₁₃N₅O₄S

InChI: InChI=1S/C10H13N5O4S/c11-10-13-7-4(8(20)14-10)12-2-15(7)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,20)/t3-,5-,6-,9-/m1/s1

InChI key: InChIKey=OTDJAMXESTUWLO-UUOKFMHZSA-N

SMILES: S=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)NC(N)=N1

Synonyms:

• 2-Amino-6-mercaptopurine ribonucleoside
• 2-Amino-6-mercaptopurine riboside
• 2-Amino-9-(β-<span class="text-smallcaps">D</span>-ribofuranosyl)purine-6-thiol
• 2-Amino-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-9H-purine-6-thiol
• 2-Amino-9-β-<span class="text-smallcaps">D</span>-ribofuranosylpurine-6-thione
• 6-Mercaptoguanine riboside
• 6-Mercaptoguanosine
• 6-Thioguanine ribonucleoside
• 6-Thioguanine riboside
• 6-Thioguanosine
• 6H-Purine-6-thione, 2-amino-1,9-dihydro-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 9-β-<span class="text-smallcaps">D</span>-Ribofuranosylthioguanine
• 9H-Purine-6(1H)-thione, 2-amino-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• Guanosine, 6-thio-
• Nsc-29422
• Thioguanosine
• 9H-Purine-6(1H)-thione, 2-amino-9-β-D-ribofuranosyl-

Guanosine, 6-thio-

CAS: 85-31-4

Formula: C₁₀H₁₃N₅O₄S

Purity: 95%

Color and Shape: Solid

Molecular weight: 299.3063

Ref: IN-DA008FMW

6-Thioguanosine

CAS: 85-31-4

6-Thioguanosine

Purity: ≥98%

Molecular weight: 299.31g/mol

Ref: 54-BUP16868

6-Thioguanosine

CAS: 85-31-4

6-Thioguanosine

Purity: 97%

Molecular weight: 299.31g/mol

Ref: 54-OR1012042

2-Amino-6-mercapto-9-(b-D-ribofuranosyl)purine hydrate

CAS: 85-31-4

Ref: 7W-GN4875

6-Thioguanosine

CAS: 85-31-4

6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.

Formula: C₁₀H₁₃N₅O₄S

Purity: 97.05%

Color and Shape: Yellow-Green Powder

Molecular weight: 299.31

Ref: TM-T20511

6-Mercaptoguanosine

CAS: 85-31-4

Purity: >98%

Color and Shape: Solid

Molecular weight: 299.309997558594

Ref: 10-M02110

6-Thioguanosine

CAS: 85-31-4

6-Thioguanosine is a purine analog that is used in the treatment of skin cancer and bowel disease. It has been shown to be an inhibitor of leukemia cells and also inhibits the growth of colon cancer cells. 6-Thioguanosine binds to the rate constant for uridine phosphorylation, which prevents the production of DNA. This drug also has an anti-inflammatory effect on bowel disease, which may be due to its ability to inhibit bcl-2 protein expression.
6-Thioguanosine is a fluorescent derivative that can be used as a substrate for x-ray diffraction data or as a biological sample in biological studies.

Formula: C₁₀H₁₃N₅O₄S

Purity: Min. 95%

Color and Shape: Slightly Yellow Slightly Green Powder

Molecular weight: 299.31 g/mol

Ref: 3D-NT04480