CAS 85-61-0

Coenzyme A

Description:

Coenzyme A (CoA) is a vital cofactor in various biochemical reactions, primarily involved in the metabolism of fatty acids and carbohydrates. It is a complex molecule composed of adenosine, pantothenic acid (vitamin B5), and a mercaptoethylamine group. CoA plays a crucial role in the formation of acetyl-CoA, which is a key substrate for the citric acid cycle, facilitating energy production in cells. The substance is characterized by its ability to form thioester bonds, which are essential for the activation of acyl groups in metabolic pathways. Coenzyme A is soluble in water and exhibits a high degree of reactivity due to the presence of its thiol group, allowing it to participate in various enzymatic reactions. Its structure enables it to act as a carrier for acyl groups, making it indispensable in the synthesis and degradation of fatty acids and the metabolism of amino acids. Overall, Coenzyme A is integral to cellular energy metabolism and the synthesis of important biomolecules.

Formula: C₂₁H₃₆N₇O₁₆P₃S

InChI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1

InChI key: InChIKey=RGJOEKWQDUBAIZ-IBOSZNHHSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OCC([C@H](C(NCCC(NCCS)=O)=O)O)(C)C)(=O)O)(=O)O)[C@H]1OP(=O)(O)O

Synonyms:

• <span class="text-smallcaps">D</span>-Coenzyme A
• Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester
• Adenosine 5'-(trihydrogen diphosphate), 3'-(dihydrogen phosphate), P'-[3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester, (R)-
• Aluzime
• COA
• CoASH
• Coa-Sh
• Coalip
• Coenzym A
• Coenzyme A Free Acid From Yeast
• Coenzyme A Hydrate
• Coenzyme A, free acid, lyophilized, 75%
• Coenzyme A, free acid, lyophilized, min. 75% (enzym.)
• Coenzyme ASH
• Coenzyme a, free acid
• D-Coenzyme A
• Lucina
• Reduced CoA
• Thiol-CoA
• [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate (non-preferred name)
• [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3S)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate (non-preferred name)
• [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl 3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate (non-preferred name)
• coenzima A

Coenzyme A Free Acid

CAS: 85-61-0

Coenzyme A Free Acid

Formula: C₂₁H₃₆N₇O₁₆P₃S

Purity: ≥95.0%

Color and Shape: Pale yellow Solid-Powder

Molecular weight: 767.53412

Ref: 54-BIA0812

Coenzyme A

CAS: 85-61-0

Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.

Formula: C₂₁H₃₆N₇O₁₆P₃S

Purity: 93.84%

Color and Shape: Solid

Molecular weight: 767.53

Ref: TM-T10857

Coenzyme A

CAS: 85-61-0

Coenzyme A

Formula: C₂₁H₃₆N₇O₁₆P₃S

Purity: ≥90%

Color and Shape: Solid

Molecular weight: 767.53

Ref: 54-BUP15611

Coenzyme A hydrate

CAS: 85-61-0

Formula: C₂₁H₃₆N₇O₁₆P₃S·xH₂O

Purity: ≥ 90.0%

Color and Shape: White to off-white or pale yellow powder

Molecular weight: 767.53 (anhydrous)

Ref: 7W-GK0114

Coenzyme A free acid

CAS: 85-61-0

Formula: C21H36N7O16P3S

Purity: >94%

Color and Shape: Solid

Molecular weight: 767.54

Ref: 48-19-1001

Coenzyme A

CAS: 85-61-0

(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy((R)-3-hydroxy-2,2-dimethyl-3-((2-((2-sulfanylethyl)carbamoyl)ethyl)carbamoyl)propoxy)phosphoryl)oxy)phosphoryl)oxy)methyl)oxolan-3-yl)oxy)phosphonic acid

Formula: C₂₁H₃₆N₇O₁₆P₃S

Purity: 85%

Molecular weight: 767.53

Ref: IN-DG122138

Coenzyme A hydrate

CAS: 85-61-0

Coenzyme A hydrate is essential in the metabolism of fatty acids and the synthesis of acetyl-CoA. It is also employed in pharmaceutical applications, especially in drug development and formulation. Its distinctive properties improve drug solubility and bioavailability, making it an essential component in the creation of therapeutic agents.

Formula: C₂₁H₃₆N₇O₁₆P₃S·xH₂O

Purity: (Enzymatic) Min. 75%

Color and Shape: White Off-White Slightly Yellow Powder

Molecular weight: 767.54 g/mol

Ref: 3D-NC45965

Coenzyme A Free Acid extrapure, 90%

CAS: 85-61-0

Formula: C₂₁H₃₆N₇O₁₆P₃S

Purity: min. 90%

Color and Shape: Almost white to slightly yellowish, Lyophilized powder

Molecular weight: 767.54

Ref: SR-40804

Coenzyme A, Free Acid

CAS: 85-61-0

Purity: 95%

Molecular weight: 767.115

Ref: 10-C300023

Coenzyme A S-Pyrazinecarboxylate Trisodium Salt

Controlled Product

CAS: 85-61-0

Applications Coenzyme A S-Pyrazinecarboxylate is a derivative of Coenzyme A (C636400); a cofactor in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase.
References Strickland K.C. et al.: J. Biol. Chem., 285, 1627 (2010); Elovson J. et al.: J. Biol. Chem., 243, 3603 (1968)

Formula: C₂₆H₃₅N₉Na₃O₁₇P₃S

Color and Shape: Neat

Molecular weight: 939.56

Ref: TR-C636415