CAS 850180-76-6

3-Azidopropanoic acid NHS ester

Description:

3-Azidopropanoic acid NHS ester is a chemical compound characterized by the presence of an azide functional group and an N-hydroxysuccinimide (NHS) ester moiety. This compound is typically used in bioconjugation and labeling applications due to its ability to react with amines, facilitating the attachment of biomolecules such as proteins or peptides. The azide group is notable for its stability and reactivity, particularly in click chemistry reactions, allowing for selective and efficient conjugation processes. The NHS ester enhances the reactivity of the carboxylic acid, making it more amenable to nucleophilic attack by amines. This compound is often utilized in the synthesis of various bioconjugates, enabling researchers to study protein interactions, cellular processes, and drug delivery systems. Additionally, 3-Azidopropanoic acid NHS ester is soluble in common organic solvents, which aids in its application in laboratory settings. As with many azide-containing compounds, appropriate safety precautions should be taken due to the potential hazards associated with azides.

Formula: C₇H₈N₄O₄

Synonyms:

• 3-Azidopropanoic acid NHS ester
• 3-azidopropanoate-N-hydroxysuccinimide ester
• N3-C2-NHS ester
• (2,5-Dioxopyrrolidin-1-yl) 3-azidopropanoate

3-azidopropanoate-N-hydroxysuccinimide ester

CAS: 850180-76-6

Formula: C₇H₈N₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 212.1628

Ref: IN-DA003IYC

N3-C2-NHS ester

CAS: 850180-76-6

N3-C2-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker employed for the synthesis of ADCs.

Formula: C₇H₈N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 212.16

Ref: TM-T18465

3-Azidopropanoate-N-hydroxysuccinimide ester

CAS: 850180-76-6

3-Azidopropanoate-N-hydroxysuccinimide ester is a fluorescent probe that can be activated by the addition of an azide donor. The fluorescence of 3-azidopropanoate-N-hydroxysuccinimide ester is dependent on the presence of serum albumin and can be used as a model system for studying albumin uptake and metabolism. This probe has been shown to have good uptake in lung cancer cells, which may be due to its ability to bind with the receptor on the cell surface. 3-Azidopropanoate-N-hydroxysuccinimide ester binds to proteolytic enzymes such as plasmin, cathepsins, and elastase, which are found in high concentrations in lung cancer cells.

Formula: C₇H₈N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 212.16 g/mol

Ref: 3D-AJB18076