CAS 85026-87-5

2'-deoxy-N-[(7S,8R,9S,10R)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl]guanosine

Description:

2'-Deoxy-N-[(7S,8R,9S,10R)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl]guanosine is a complex nucleoside derivative characterized by its unique structural features. This compound consists of a guanosine backbone, which is a purine nucleoside, modified by the attachment of a tetrahydrobenzo compound that includes multiple hydroxyl groups. The presence of these hydroxyl groups contributes to its potential solubility and reactivity, influencing its biological activity. The stereochemistry indicated by the (7S,8R,9S,10R) configuration suggests specific spatial arrangements that may affect how the molecule interacts with biological targets, such as enzymes or receptors. This compound may exhibit properties relevant to medicinal chemistry, particularly in the context of antiviral or anticancer research, due to its structural complexity and potential for mimicking natural nucleosides. Its CAS number, 85026-87-5, allows for precise identification in chemical databases, facilitating further research and application in various scientific fields.

Formula: C₃₀H₂₇N₅O₇

InChI: InChI=1/C30H27N5O7/c36-10-18-17(37)9-19(42-18)35-11-31-24-28(35)33-30(34-29(24)41)32-23-22-15-7-6-13-3-1-2-12-4-5-14(21(15)20(12)13)8-16(22)25(38)27(40)26(23)39/h1-8,11,17-19,23,25-27,36-40H,9-10H2,(H2,32,33,34,41)/t17-,18+,19+,23+,25-,26-,27+/m0/s1

(-)-trans-anti-N2-BPDE-dG-d8

Controlled Product

CAS: 85026-87-5

Formula: C₃₀H₁₉D₈N₅O₇

Color and Shape: Neat

Molecular weight: 594.69

Ref: TR-B676632

(-)-trans-anti-N2-BPDE-dG

Controlled Product

CAS: 85026-87-5

Formula: C₃₀H₂₇N₅O₇

Color and Shape: Neat

Molecular weight: 376.488

Ref: TR-B676630

(+/-)-trans-anti-N2-BPDE-dG-15N5

Controlled Product

CAS: 85026-87-5

Applications (+/-)-trans-anti-N2-BPDE-dG-15N5 is an isotope labelled analog of (-)-trans-anti-N2-BPDE-dG (B676630), which is used in the study of carcinogen-DNA adducts and their role in affecting eukaryotic DNA methyltransferases. Cluster-type DNA damage is often seen in DNA and is usually skipped by base excision repair.
References Skosareva, L. et al.: DNA Repair., 11, 367 (2012); Minero, A. et al.: FEBS J. et al.: 279, 3965 (2012); Hoare, S. et al.: Biochem., 39, 12252 (2000); Subach, O. et al.: Biochem., 45, 6142 (2006);

Formula: C₃₀H₂₉₁₅N₅O₇

Color and Shape: Neat

Molecular weight: 576.548

Ref: TR-B676633

(+/-)-cis-anti-N2-BPDE-dG-15N5

Controlled Product

CAS: 85026-87-5

Applications (+/-)-cis-anti-N2-BPDE-dG-15N5 is an isotope labelled analog of (-)-trans-anti-N2-BPDE-dG (B676630), which is used in the study of carcinogen-DNA adducts and their role in affecting eukaryotic DNA methyltransferases. Cluster-type DNA damage is often seen in DNA and is usually skipped by base excision repair.
References Skosareva, L. et al.: DNA Repair., 11, 367 (2012); Minero, A. et al.: FEBS J. et al.: 279, 3965 (2012); Hoare, S. et al.: Biochem., 39, 12252 (2000); Subach, O. et al.: Biochem., 45, 6142 (2006);

Formula: C₃₀H₂₉₁₅N₅O₇

Color and Shape: Neat

Molecular weight: 576.548

Ref: TR-B676638