CAS 850649-62-6
:Alogliptin benzoate
Description:
Alogliptin benzoate is a pharmaceutical compound primarily used as an antidiabetic agent, specifically for the management of type 2 diabetes mellitus. It functions as a dipeptidyl peptidase-4 (DPP-4) inhibitor, which helps to increase insulin secretion and decrease glucagon levels in the bloodstream, thereby improving glycemic control. The compound is characterized by its benzoate ester form, which enhances its solubility and bioavailability. Alogliptin benzoate is typically administered orally and is known for its favorable safety profile, with common side effects including headache and gastrointestinal disturbances. Its mechanism of action involves the inhibition of the DPP-4 enzyme, leading to prolonged activity of incretin hormones, which are crucial for glucose metabolism. The substance is often used in combination with other antidiabetic medications to achieve better glycemic control. As with any medication, it is essential to consider potential drug interactions and contraindications when prescribing or using alogliptin benzoate.
Formula:C18H21N5O2·C7H6O2
InChI:InChI=1S/C18H21N5O2.C7H6O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19;8-7(9)6-4-2-1-3-5-6/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3;1-5H,(H,8,9)/t15-;/m1./s1
InChI key:InChIKey=KEJICOXJTRHYAK-XFULWGLBSA-N
SMILES:C(N1C(=CC(=O)N(C)C1=O)N2C[C@H](N)CCC2)C3=C(C#N)C=CC=C3.C(O)(=O)C1=CC=CC=C1
Synonyms:- 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile benzoate
- Alogliptin Benzoate
- Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, benzoate (1:1)
- Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, monobenzoate
- Nesina
- Syr-322
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Found 8 products.
Alogliptin
CAS:Formula:C18H21N5O2Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:339.39Alogliptin Benzoate
CAS:Formula:C18H21N5O2·C7H6O2Color and Shape:White To Off-White SolidMolecular weight:339.40 122.12Alogliptin Benzoate
CAS:Alogliptin Benzoate, a potent DPP-4 inhibitor with >10,000-fold selectivity over DPP-8/9, may also curb TLR-4-induced inflammation.Formula:C25H27N5O4Purity:99.94% - >99.99%Color and Shape:White PowderMolecular weight:461.51Alogliptin Benzoate
CAS:<p>Applications Alogliptin Benzoate is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Alogliptin Benzoate is used in the treatment of type 2 diabetes.<br>References Wang, Y., et. al.: Drugs Future, 33, 7 (2008); Lynn, F., et al.: Diabetes, 50, 1004 (2001); Trumper, A., et al.: J. Endocrinol., 174, 233 (2002); Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009)<br></p>Formula:C18H21N5O2·C7H6O2Color and Shape:NeatMolecular weight:461.51Alogliptin benzoate
CAS:<p>Alogliptin benzoate is an orally active DPP-IV inhibitor that is used for the treatment of type 2 diabetes. Alogliptin benzoate is a prodrug that is hydrolyzed to alogliptin in vivo, which binds to the DPP-IV enzyme and blocks it from degrading the incretin hormones, GLP-1 and GIP. These hormones are released by the ileum after a meal and act on pancreatic beta cells to release insulin. Alogliptin benzoate has been shown to improve glucose levels after a meal, while reducing postprandial glucagon levels, as well as improving insulin sensitivity in patients with type 2 diabetes mellitus. Alogliptin benzoate also reduces bowel disease symptoms such as abdominal pain, diarrhea, and constipation in patients with type 2 diabetes. The analytical method used for measuring alogliptin benzoate concentration in plasma or serum is chromatographic analysis with postpr</p>Formula:C18H21N5O2C7H6O2Purity:Min. 95%Color and Shape:White PowderMolecular weight:461.51 g/mol
