CAS 850876-88-9

Danoprevir

Description:

Danoprevir is an antiviral medication primarily used in the treatment of hepatitis C virus (HCV) infections. It belongs to the class of drugs known as protease inhibitors, which work by inhibiting the viral protease enzyme, thereby preventing the replication of the virus. Danoprevir is characterized by its specific chemical structure, which includes a series of functional groups that contribute to its activity and solubility. The compound is typically administered in combination with other antiviral agents to enhance its efficacy and reduce the potential for viral resistance. Danoprevir has shown a favorable pharmacokinetic profile, with good oral bioavailability and a relatively long half-life, allowing for convenient dosing regimens. Its safety profile includes common side effects associated with antiviral therapies, such as fatigue, nausea, and potential liver enzyme elevations. Overall, Danoprevir represents a significant advancement in the treatment of chronic hepatitis C, particularly in specific genotypes of the virus.

Formula: C₃₅H₄₆FN₅O₉S

InChI: InChI=1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7-/t22-,23-,27+,28+,35-/m1/s1

InChI key: InChIKey=ZVTDLPBHTSMEJZ-JSZLBQEHSA-N

SMILES: C(NS(=O)(=O)C1CC1)(=O)[C@]23[C@@](C2)(/C=C\CCCCC[C@H](NC(OC(C)(C)C)=O)C(=O)N4[C@](C(=O)N3)(C[C@@H](OC(=O)N5CC=6C(C5)=C(F)C=CC6)C4)[H])[H]

Synonyms:

• Danoprevir
• CS-64
• Itmn-191(Danoprevir)
• 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
• ITMN 191
• R 7227
• 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
• 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dio
• Itmn-191
• ITMN-191
• Intermune ITMN-191
• Danpprevir
• RG7227, ITMN-191, RO5190591
• Danoprevir(ITMN-191, RG7227)
• Danoprevir - ITMN 191 | RG 7227 | R 7227
• dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191)
• R7227
• RG72277
• Danoprevir(ITMN-191)
• (2R,6S,13aS,14aR,16aS,)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
• RG7227
• ITMN-191; R7227; RO5190591; RG7227;ITMN191;ITMN 191
• Danoprevir (RG7227)
• Intepirdine
• (2R,6S,13aS,14aR,16aS,E)-6-((tert-butoxycarbonyl)aMino)-14a-((cyclopropylsulfonyl)carbaMoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
• (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
• Danoprevir, >=98%

RG7227, ITMN-191, RO5190591

CAS: 850876-88-9

Formula: C₃₅H₄₆FN₅O₉S

Purity: 99%

Color and Shape: Solid

Molecular weight: 731.8312

Ref: IN-DA00G3O6

Danoprevir

CAS: 850876-88-9

Danoprevir

Purity: ≥98%

Molecular weight: 731.83g/mol

Ref: 54-BUP04844

Danoprevir

CAS: 850876-88-9

Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).

Formula: C₃₅H₄₆FN₅O₉S

Purity: 98% - 99.80%

Color and Shape: Solid

Molecular weight: 731.83

Ref: TM-T6025

Danoprevir

Controlled Product

CAS: 850876-88-9

Applications Danoprevir is a selective and potent inhibitor of Hepatitis C virus.
References Ali, A. et al.: ACS. Chem. Biol., 8, 1469 (2013); Rong, L. et al.: PLoS. Comp. Biol., 9, e1002959 (2013);

Formula: C₃₅H₄₆FN₅O₉S

Color and Shape: Neat

Molecular weight: 731.83

Ref: TR-D172820

Danoprevir

CAS: 850876-88-9

Danoprevir is an inhibitor of the viral protease. It is used in combination with other antiviral drugs for the treatment of hepatitis C virus (HCV) infections. Danoprevir has been shown to inhibit a number of resistant mutants, including protease-resistant mutants, which may have contributed to its effectiveness against HCV. The drug inhibits the activity of other enzymes, such as HIV-1 protease and influenza virus NS1 proteinase. Danoprevir has also been shown to be effective against HCV infection in animal models.

Formula: C₃₅H₄₆FN₅O₉S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 731.83 g/mol

Ref: 3D-FD106410