CAS 851443-04-4

Rosuvastatin ethyl ester

Description:

Rosuvastatin ethyl ester, with the CAS number 851443-04-4, is a synthetic compound belonging to the statin class of drugs, primarily used for lowering cholesterol levels and managing cardiovascular diseases. It is an ester derivative of rosuvastatin, which is known for its ability to inhibit HMG-CoA reductase, an enzyme crucial in the cholesterol biosynthesis pathway. The compound typically appears as a white to off-white solid and is characterized by its lipophilic nature, which enhances its bioavailability. Rosuvastatin ethyl ester is soluble in organic solvents but has limited solubility in water. Its pharmacological profile includes a potent effect on reducing low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. The compound undergoes hydrolysis in the body to yield the active form, rosuvastatin, which exerts its therapeutic effects. As with other statins, potential side effects may include muscle pain, liver enzyme alterations, and gastrointestinal disturbances, necessitating monitoring during treatment.

Formula: C₂₄H₃₂FN₃O₆S

InChI: InChI=1/C24H32FN3O6S/c1-6-34-21(31)14-19(30)13-18(29)11-12-20-22(15(2)3)26-24(28(4)35(5,32)33)27-23(20)16-7-9-17(25)10-8-16/h7-12,15,18-19,29-30H,6,13-14H2,1-5H3/b12-11+/t18-,19-/m1/s1

Synonyms:

• 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester
• Rosuvastatine
• ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

Ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoate

CAS: 851443-04-4

Formula: C₂₄H₃₂FN₃O₆S

Purity: 99%

Color and Shape: Solid

Molecular weight: 509.5908

Ref: IN-DA004QSB

Rosuvastatin Ethyl Ester

CAS: 851443-04-4

Formula: C₂₄H₃₂FN₃O₆S

Color and Shape: White To Off-White Solid

Molecular weight: 509.59

Ref: 4Z-R-0928

Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

CAS: 851443-04-4

Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

Purity: 99%

Molecular weight: 509.6g/mol

Ref: 54-PC1006224

Rosuvastatin Ethyl Ester

CAS: 851443-04-4

Color and Shape: Off-White To Light Beige

Ref: 86-MM0936.38

Rosuvastatin Ethyl Ester

CAS: 851443-04-4

Applications Rosuvastatin ethyl ester (CAS# 851443-04-4) is an intermediate formed during the synthetic preparation of rosuvastatin, a pharmaceutical used to manage LDL cholesterol.
References Sterk, D.; et al.: Tetrahedron Lett., 57, 1338 (2016); Olsson, A. G.; et al.: Am. Heart J., 144, 1044 (2002).

Formula: C₂₄H₃₂FN₃O₆S

Color and Shape: Off-White To Light Beige

Molecular weight: 509.59

Ref: TR-R700723

Rosuvastatin FP Impurity A

CAS: 851443-04-4

Formula: C₂₄H₃₂FN₃O₆S

Molecular weight: 509.59

Ref: ST-EA-CP-R1020

7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl es ter

CAS: 851443-04-4

Rosuvastatin is a statin drug that inhibits cholesterol synthesis by inhibiting the enzyme HMG-CoA reductase. Rosuvastatin has been shown to reduce high-sensitivity C-reactive protein (hsCRP) and low-density lipoprotein cholesterol (LDL-C), which are risk factors for cardiovascular disease, in patients with hypercholesterolemia. Rosuvastatin also has a high degree of potency and specificity for the HMG-CoA reductase enzyme and shows no significant cross-reactivity with other HMG-CoA reductase inhibitors. Rosuvastatin is metabolized by CYP3A4 and CYP2C9. Drugs that inhibit these enzymes may increase the plasma levels of rosuvastatin, while drugs that induce these enzymes may decrease the plasma levels of rosuvastatin.

Formula: C₂₄H₃₂FN₃O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 509.59 g/mol

Ref: 3D-FF35383

Rosuvastatin Ethyl Ester (Ethyl (3R,5S,E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate)

CAS: 851443-04-4

Sulfonamides, nesoi

Formula: C₂₄H₃₂FN₃O₆S

Color and Shape: Off-White Powder

Molecular weight: 509.19959

Ref: 45-1A06130