CAS 851627-62-8

PR 104

Description:

PR 104, with the CAS number 851627-62-8, is a chemical compound that belongs to a class of substances known as bioreductive prodrugs. It is primarily characterized by its ability to undergo metabolic activation in hypoxic (low oxygen) conditions, which is particularly relevant in the context of cancer therapy. The compound is designed to selectively target and damage hypoxic tumor cells, making it a potential candidate for use in cancer treatments. PR 104 is a phosphoramide derivative, and its mechanism of action involves the reduction of its nitro groups to generate cytotoxic agents that can induce cell death in malignant cells. Additionally, PR 104 has been studied for its pharmacokinetics, stability, and efficacy in preclinical and clinical settings. Its development reflects ongoing efforts to improve the selectivity and effectiveness of chemotherapeutic agents, particularly in solid tumors where hypoxia is a common feature. As with any pharmaceutical compound, understanding its safety profile and potential side effects is crucial for its therapeutic application.

Formula: C₁₄H₂₀BrN₄O₁₂PS

InChI: InChI=1S/C14H20BrN4O12PS/c1-33(28,29)31-7-5-17(4-2-15)13-11(14(20)16-3-6-30-32(25,26)27)8-10(18(21)22)9-12(13)19(23)24/h8-9H,2-7H2,1H3,(H,16,20)(H2,25,26,27)

InChI key: InChIKey=GZSOKPMDWVRVMG-UHFFFAOYSA-N

SMILES: N(CCOS(C)(=O)=O)(CCBr)C1=C(C(NCCOP(=O)(O)O)=O)C=C(N(=O)=O)C=C1N(=O)=O

Synonyms:

• 2-((2-Bromoethyl)(2,4-dinitro-6-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate
• PR 104
• 2-[(2-Bromoethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitro-N-[2-(phosphonooxy)ethyl]benzamide
• 2-[N-(2-Bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl]anilino]ethyl methanesulfonate
• Benzamide, 2-[(2-bromoethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitro-N-[2-(phosphonooxy)ethyl]-

PR-104

CAS: 851627-62-8

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Formula: C₁₄H₂₀BrN₄O₁₂PS

Purity: Min. 95%

Molecular weight: 579.27 g/mol

Ref: 3D-BP183373

PR-104

CAS: 851627-62-8

PR-104: hypoxia-activated DNA cross-linker, pre-prodrug for nitrogen mustard, converts to PR-104A in tumors.

Formula: C₁₄H₂₀BrN₄O₁₂PS

Color and Shape: Solid

Molecular weight: 579.27

Ref: TM-T36302