CAS 85175-67-3

Zatebradine

Description:

Zatebradine is a chemical compound primarily recognized for its role as a selective bradycardic agent, which means it is used to lower heart rate without significantly affecting myocardial contractility. It functions by inhibiting the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, particularly HCN4, which are involved in the pacemaker activity of the heart. This mechanism makes Zatebradine useful in treating conditions such as chronic heart failure and angina pectoris. The compound is characterized by its specific molecular structure, which includes a unique arrangement of atoms that contributes to its pharmacological properties. Zatebradine is typically administered in oral form and has been studied for its potential benefits in improving cardiac function and exercise tolerance in patients with heart-related issues. As with any medication, its use may be accompanied by side effects, and it is essential to consider patient-specific factors when prescribing it. Overall, Zatebradine represents a significant advancement in the management of heart rate-related disorders.

Formula: C₂₆H₃₆N₂O₅

InChI: InChI=1/C26H36N2O5/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29/h7-8,15-17H,6,9-14,18H2,1-5H3

SMILES: CN(CCCN1CCc2cc(c(cc2CC1=O)OC)OC)CCc1ccc(c(c1)OC)OC

Synonyms:

• Zatebradine [INN]
• 3-(3-((3,4-Dimethoxyphenethyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one
• Unii-Tv27Ry5876
• Zatebradina
• Zatebradina [INN-Spanish]
• Zatebradinum
• Zatebradinum [INN-Latin]
• 3-(3-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

Zatebradine

CAS: 85175-67-3

Formula: C₂₆H₃₆N₂O₅

Purity: 99.59%

Color and Shape: Solid

Molecular weight: 456.5744

Ref: IN-DA00G3RO

Zatebradine

CAS: 85175-67-3

Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).

Formula: C₂₆H₃₆N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 456.57

Ref: TM-T13387

Zatebradine

CAS: 85175-67-3

Zatebradine is a cardiotonic drug that has been shown to be effective in the treatment of bowel disease. It is also used for the prevention and treatment of anesthetized, ventricular, and heart rate changes in humans. Zatebradine has been shown to increase the energy metabolism of cardiac muscle cells and improve the function of papillary muscles. In addition, zatebradine can treat structural heart disease such as congestive heart failure or atrial arrhythmias. The drug has been shown to reduce systolic pressure in people with cardiac diseases and inflammatory bowel disease.

Formula: C₂₆H₃₆N₂O₅

Purity: Min. 95%

Molecular weight: 456.57 g/mol

Ref: 3D-KDA17567