CAS 851884-87-2

GKA-50

Description:

GKA-50, identified by its CAS number 851884-87-2, is a chemical compound that has garnered attention in various fields, particularly in research and development. While specific characteristics can vary based on its formulation and application, GKA-50 is typically recognized for its unique molecular structure, which may impart specific physical and chemical properties such as solubility, stability, and reactivity. It is often studied for its potential applications in pharmaceuticals, agrochemicals, or materials science. The compound may exhibit particular biological activities, making it a candidate for further investigation in medicinal chemistry. Safety data sheets and regulatory information should be consulted for handling and usage guidelines, as with any chemical substance. Overall, GKA-50 represents a class of compounds that could contribute to advancements in various scientific domains, although detailed empirical data would be necessary for a comprehensive understanding of its characteristics and applications.

Formula: C₂₆H₂₈N₂O₆

Synonyms:

• GKA-50; GKA 50
• GKA 50
• GKA-50
• OCBMECSFDVUYQN-ROUUACIJSA-N
• 6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid
• GKA50

6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid

Controlled Product

CAS: 851884-87-2

Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.
References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);

Formula: C₂₆H₂₈N₂O₆

Color and Shape: Neat

Molecular weight: 464.51

Ref: TR-M264215

6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5

Controlled Product

CAS: 851884-87-2

Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5 is the labeled analogue of (M264215), which is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.
References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);

Formula: C₂₆D₅H₂₃N₂O₆

Color and Shape: Neat

Molecular weight: 469.541

Ref: TR-M264217

GKA 50

CAS: 851884-87-2

Glucokinase activator

Formula: C₂₆H₂₈N₂O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 464.51 g/mol

Ref: 3D-BG167877

GKA50

CAS: 851884-87-2

GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).

Formula: C₂₆H₂₈N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 464.51

Ref: TM-T11401