CAS 85233-19-8

BAPTA

Description:

BAPTA, or bis-(o-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, is a chelating agent primarily used for its ability to bind calcium ions with high specificity. It features a structure that includes two o-aminophenoxy groups and four acetic acid moieties, which facilitate its interaction with metal ions. BAPTA is particularly valued in biochemical research for its role in studying calcium signaling pathways, as it can effectively sequester calcium ions, thereby modulating cellular responses. The compound is often utilized in cell culture and physiological experiments to control intracellular calcium levels. BAPTA is known for its relatively low membrane permeability compared to other calcium chelators, making it suitable for applications where localized calcium buffering is required. Additionally, BAPTA can exist in various forms, including its free acid and various salt forms, which can influence its solubility and reactivity. Overall, BAPTA is a crucial tool in the fields of biochemistry and cell biology, aiding in the understanding of calcium's role in cellular processes.

Formula: C₂₂H₂₄N₂O₁₀

InChI: InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)

InChI key: InChIKey=FTEDXVNDVHYDQW-UHFFFAOYSA-N

SMILES: N(CC(O)=O)(CC(O)=O)C1=C(OCCOC2=C(N(CC(O)=O)CC(O)=O)C=CC=C2)C=CC=C1

Synonyms:

• 1,2-Bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
• 2,2',2'',2'''-[Ethane-1,2-Diylbis(Oxybenzene-2,1-Diylnitrilo)]Tetraacetate
• 2,2',2'',2'''-[Ethane-1,2-Diylbis(Oxybenzene-2,1-Diylnitrilo)]Tetraacetic Acid
• 2-[2-[2-[2-[Bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid
• Bapta
• Glycine, N,N′-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-
• N,N′-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine]
• 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
• 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid

BAPTA, 97%

CAS: 85233-19-8

Acts as a calcium chelatorBAPTA is used as a selective calcium chelating reagent. It is suitable for the spectrophotometric monitoring of calcium levels. It is a lipophilic diesters of the chelating agent used for the inhibition of proteolytic activities of certain metalloproteinases, calpain and tr

Formula: C₂₂H₂₄N₂O₁₀

Purity: 97%

Color and Shape: White to pale cream to pale yellow, Powder

Molecular weight: 476.44

Ref: 02-A13190

Glycine,N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-

CAS: 85233-19-8

Formula: C₂₂H₂₄N₂O₁₀

Purity: 97%

Color and Shape: Solid

Molecular weight: 476.4334

Ref: IN-DA00IDLE

1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

CAS: 85233-19-8

1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

Formula: C₂₂H₂₄N₂O₁₀

Purity: 97%

Color and Shape: pale yellow solid

Molecular weight: 476.43335g/mol

Ref: 54-OR2350T

BAPTA

CAS: 85233-19-8

BAPTA

Purity: ≥95%

Molecular weight: 476.43g/mol

Ref: 54-BUP14798

1,2-Bis(2-aminophenoxy)ethane-N,N,N'',N''-tetraacetic acid

CAS: 85233-19-8

Formula: C₂₂H₂₄N₂O₁₀

Purity: ≥ 97.0%

Color and Shape: White to off-white or faint beige powder

Molecular weight: 476.44

Ref: 7W-GK0328

BAPTA (1,2-bis(o-Aminophenoxy)ethane-N,N,N',N'-tetra-Acetic Acid)

CAS: 85233-19-8

Formula: C₂₂H₂₄N₂O₁₀

Molecular weight: 476.44

Ref: 4Z-A-138070

BAPTA

CAS: 85233-19-8

BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.

Formula: C₂₂H₂₄N₂O₁₀

Purity: 96.28% - ≥95%

Color and Shape: White Solid

Molecular weight: 476.43

Ref: TM-T7098

BAPTA

Controlled Product

CAS: 85233-19-8

Applications BAPTA is a highly selective calcium chelating reagent. Lipophilic diesters of the chelating agent 1,2-Bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) are used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE.
References Tsien, R.Y., Biochemistry, 19, 2396 (1980), Wu, S.Y., et al.: J. Neurophysiology, 74, 2600 (1995), Venant, A., et al.: Biol. Cell, 85, 197 (1995), Tucker, T., et al.: Neuron, 15, 1323 (1995)

Formula: C₂₂H₂₄N₂O₁₀

Color and Shape: Neat

Molecular weight: 476.43

Ref: TR-B123500

BAPTA

CAS: 85233-19-8

BAPTA is a fluorescent probe that binds to cytosolic calcium and can be used to measure intracellular calcium levels. It can also be used as a fluorescence probe for the measurement of mitochondrial membrane potential. BAPTA is a potent inhibitor of neuronal death induced by excess cytosolic calcium, which leads to activation of calcium-dependent proteases and cell lysis. The mechanism by which BAPTA inhibits neuronal death is unclear, but it may be due to its ability to modulate mitochondrial membrane potential or regulate Ca2+ release from intracellular stores. BAPTA has been shown to inhibit the polymerase chain reaction (PCR) in cells and tissues and can also inhibit the transcriptional activity of nuclear DNA. In addition, BAPTA can inhibit the function of ryanodine receptors in cells, leading to an increase in cytosolic Ca2+.

Formula: C₂₂H₂₄N₂O₁₀

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 476.43 g/mol

Ref: 3D-FB16297

Tetrasodium 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate

CAS: 126824-24-6, 336624-09-0, 85233-19-8

Formula: C₂₂H₂₀N₂Na₄O₁₀

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 564.37

Ref: 3B-T2844

1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid

CAS: 85233-19-8

Formula: C₂₂H₂₄N₂O₁₀

Purity: >97.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 476.44

Ref: 3B-B3895

BAPTA Free Acid extrapure, 98%

CAS: 85233-19-8

Formula: C₂₂H₂₄N₂O₁₀

Molecular weight: 476.43

Ref: SR-34501

BAPTA

CAS: 85233-19-8

Purity: 97%

Molecular weight: 476.4379883

Ref: 10-F799092