CAS 85547-56-4

Piperaquine phosphate

Description:

Piperaquine phosphate is an antimalarial compound primarily used in the treatment of malaria, particularly in combination therapies with artemisinin derivatives. It is a bisquinoline derivative, characterized by its long half-life and ability to provide sustained therapeutic levels in the body, which helps in preventing relapse of malaria. The substance is typically administered as a phosphate salt, enhancing its solubility and bioavailability. Piperaquine exhibits a mechanism of action that involves interference with the heme detoxification process in the malaria parasite, leading to its death. It is generally well-tolerated, but like many medications, it can have side effects, including gastrointestinal disturbances and potential cardiovascular effects. The compound is often used in regions where malaria is endemic, and its efficacy is enhanced when used in conjunction with other antimalarial agents. Due to its pharmacokinetic properties, piperaquine is particularly valuable in malaria treatment regimens that require prolonged action to combat resistant strains of the parasite.

Formula: C₂₉H₃₂Cl₂N₆·xH₃O₄P

InChI: InChI=1S/C29H32Cl2N6.H3O4P/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29;1-5(2,3)4/h2-9,20-21H,1,10-19H2;(H3,1,2,3,4)

InChI key: InChIKey=KATNPMSTHHZOTK-UHFFFAOYSA-N

SMILES: P(=O)(O)(O)O.ClC1=CC2=C(C(=CC=N2)N3CCN(CCCN4CCN(CC4)C=5C6=C(C=C(Cl)C=C6)N=CC5)CC3)C=C1

Synonyms:

• Quinoline, 4,4′-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-, phosphate (1:?)
• Quinoline, 4,4′-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-, phosphate
• Piperaquine phosphate
• 4,4'-(Propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline) phosphate (1:1)
• 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
• quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-, phosphate (1:1)
• 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP
• 85547-56-4
• 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)
• 2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol
• antimalarial drugs PIPERAQUINE PHOSPHATE

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate

CAS: 85547-56-4

Formula: C₂₉H₃₅Cl₂N₆O₄P

Purity: 98%

Color and Shape: Solid

Molecular weight: 633.5058

Ref: IN-DA004R2T

Piperaquine phosphate

CAS: 85547-56-4

Piperaquine phosphate

Purity: ≥98%

Molecular weight: 535.52g/mol

Ref: 54-BUP18699

Piperaquine phosphate

CAS: 85547-56-4

Piperaquine phosphate is an antimalarial compound commonly used in combination with artemisinin to inhibit Plasmodium falciparum.

Formula: C₂₉H₃₂Cl₂N₆xH₃O₄P

Purity: 99.17%

Color and Shape: Solid

Molecular weight: 535.52(Free base)

Ref: TM-T22400

Piperaquine phosphate

Controlled Product

CAS: 85547-56-4

Piperaquine phosphate is an anti-malarial drug that is used to treat acute and uncomplicated malaria. It is a prodrug that is activated in the liver by hydrolysis of the ester group to produce piperaquine, which has antimalarial activity. Piperaquine phosphate can be used in patients with hepatic impairment or those who have developed resistance to other drugs. Studies have shown that this drug can be administered orally or intravenously and has a good pharmacokinetic profile. This agent has been shown to be safe for use in pregnant women, although it may cause birth defects if taken during the first trimester. The major adverse effects are gastrointestinal disturbances and mild skin reactions such as itching and rash.

Formula: C₂₉H₃₂Cl₂N₆•xH₃O₄P

Purity: Min. 95%

Molecular weight: 535.51 g/mol

Ref: 3D-KDA54756