CAS 85622-93-1
:Temozolomide
Description:
Temozolomide is an oral alkylating agent primarily used in the treatment of certain types of brain tumors, particularly glioblastoma multiforme and anaplastic astrocytoma. Its chemical formula is C6H6N4O2, and it is classified as a prodrug, which means it is metabolized in the body to its active form, which then exerts its therapeutic effects. Temozolomide works by methylating DNA, leading to the disruption of DNA replication and ultimately inducing apoptosis in rapidly dividing cancer cells. The substance is typically administered in capsule form and is known for its ability to cross the blood-brain barrier, making it effective for central nervous system tumors. Temozolomide is generally well-tolerated, but it can cause side effects such as nausea, vomiting, and myelosuppression. Its pharmacokinetics involve rapid absorption and metabolism, with a half-life that allows for convenient dosing schedules. Overall, Temozolomide represents a significant advancement in the chemotherapeutic management of malignant brain tumors.
Formula:C6H6N6O2
InChI:InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key:InChIKey=BPEGJWRSRHCHSN-UHFFFAOYSA-N
SMILES:C(N)(=O)C1=C2N(C(=O)N(C)N=N2)C=N1
Synonyms:- 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
- 3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide
- 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
- 3-Methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide
- 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide
- 3-Methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
- 3-Methyl-8-carbamoylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
- 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide
- 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
- Ccrg 81045
- Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-
- M and B 39831
- Mb 39831
- Methazolastone
- NSC 362856
- Sch 52365
- T 2577
- Temodal
- Temodar
- Temomedac
- See more synonyms
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Found 14 products.
Temozolomide
CAS:Formula:C6H6N6O2Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light red powder to crystalMolecular weight:194.15Temozolomide
CAS:TemozolomideFormula:C6H6N6O2Purity:99.5%Color and Shape:WhiteMolecular weight:194.05522Temozolomide
CAS:<p>Heterocyclic compounds with nitrogen hetero-atom(s) only, excluding aromatic or modified aromatic</p>Formula:C6H6N6O2Color and Shape:PowderMolecular weight:194.055223-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide
CAS:Formula:C6H6N6O2Purity:98%Color and Shape:SolidMolecular weight:194.1508Temozolomide
CAS:<p>Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity.</p>Formula:C6H6N6O2Purity:98% - 99.87%Color and Shape:Off-White To Light-Pink Crystalline SolidMolecular weight:194.15Temozolomide
CAS:<p>Temozolomide</p>Formula:C6H6N6O2Purity:98%Color and Shape: white solidMolecular weight:194.15g/molTemozolomide
CAS:Formula:C6H6N6O2Purity:≥ 98.0%Color and Shape:White to light-brown or pink powderMolecular weight:194.15Temozolomide - Bio-X ™
CAS:<p>Temozolomide is an imidazotetrazine alkylating agent. It has anti-tumor activity against a broad spectrum of tumors, such as leukemias, lymphomas and solid tumors. Temozolomide induces G2/M arrest, preventing cells from entering mitosis and, therefore, apoptosis. As a drug resistance-modifying agent it is used for studying drug resistance mechanisms in glioblastoma cell lines.</p>Formula:C6H6N6O2Purity:Min. 98 Area-%Color and Shape:White To Pale Pink SolidMolecular weight:194.15 g/molTemozolomide
CAS:<p>Temozolomide is a cancer drug that belongs to the class of alkylating agents. It has been shown to have anticancer activity against human tumor cells in vitro. Temozolomide induces cell death by activating the apoptotic pathway. This drug also inhibits the cell cycle and blocks the G2-M phase, resulting in accumulation of cells at this point in the cell cycle. Temozolomide has been studied for its effects for cancer treatment in certain research approaches.</p>Formula:C6H6N6O2Purity:Min. 98 Area-%Color and Shape:Off-White PowderMolecular weight:194.15 g/mol3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
CAS:Formula:C6H6N6O2Purity:95%Color and Shape:SolidMolecular weight:194.154
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