CAS 856925-71-8

4H-Pyrrolo[2,3-b]quinolin-4-one,1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-

Description:

4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-, identified by CAS number 856925-71-8, is a complex organic compound characterized by its unique bicyclic structure that incorporates both pyrrole and quinoline moieties. This compound features a tetrahydro configuration, indicating the presence of a saturated ring system, and includes a hydroxyl group, which contributes to its potential reactivity and solubility in polar solvents. The methyl and phenyl substituents enhance its structural diversity and may influence its biological activity. Such compounds are often of interest in medicinal chemistry due to their potential pharmacological properties, including anti-inflammatory or anticancer activities. The stereochemistry, denoted by (3aS), suggests specific spatial arrangements of atoms that can significantly affect the compound's interactions with biological targets. Overall, this compound exemplifies the intricate relationship between molecular structure and biological function, making it a subject of interest for further research and development in various chemical and pharmaceutical applications.

Formula: C₁₈H₁₆N₂O₂

Synonyms:

• (-)-Blebbistatin

(S)-(-)-Blebbistatin

CAS: 856925-71-8

Formula: C₁₈H₁₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 292.3318

Ref: IN-DA004T4Q

(-)-Blebbistatin

CAS: 856925-71-8

(-)-Blebbistatin

Purity: ≥98%

Molecular weight: 292.33g/mol

Ref: 54-BUP05856

(-)-Blebbistatin

CAS: 856925-71-8

(-)-Blebbistatin

Purity: 98%

Molecular weight: 292.33g/mol

Ref: 54-OR1023732

(-)-Blebbistatin

CAS: 856925-71-8

Formula: C₁₈H₁₆N₂O₂

Purity: ≥ 98.0%

Color and Shape: Light-yellow to yellow powder

Molecular weight: 292.33

Ref: 7W-GL7074

(-)-Blebbistatin

CAS: 856925-71-8

(-)-Blebbistatin ((S)-(-)-Blebbistatin) is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM.

Formula: C₁₈H₁₆N₂O₂

Purity: 99.38% - 99.61%

Color and Shape: Solid

Molecular weight: 292.33

Ref: TM-T6038

(S)-(-)-Blebbistatin

Controlled Product

CAS: 856925-71-8

Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. Blebbistatin blocks both blebbing and cytokinesis at 50-100µM.[Blebbistatin:a]D= -103 (c= 1.21 CHCl3)(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneBlebbistatin is a selective inhibitor of nonmuscle myosin II; Blebbistatin inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)

Formula: C₁₈H₁₆N₂O₂

Color and Shape: Light Yellow To Yellow

Molecular weight: 292.33

Ref: TR-B592500

(S)-(-)-Blebbistatin

CAS: 856925-71-8

Inhibitor of myosin?II?specific ATPase which blocks the myosin heads in an actin-detached state, disrupts contractility of myosin-actin filaments and stabilizes super-relaxed state of muscle fibres. It inhibits skeletal muscle myosin, non-muscle myosin II and heart muscle myosin.

Formula: C₁₈H₁₆N₂O₂

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 292.3 g/mol

Ref: 3D-BB181114