CAS 857064-38-1

WP1066

Description:

WP1066, with the CAS number 857064-38-1, is a small molecule inhibitor primarily known for its role in targeting the signal transducer and activator of transcription 3 (STAT3) pathway. This compound has garnered attention in cancer research due to its potential to inhibit tumor growth and promote apoptosis in various cancer cell lines. WP1066 exhibits characteristics such as being a selective inhibitor, which allows it to interfere with the phosphorylation and activation of STAT3, a transcription factor often implicated in oncogenesis and tumor progression. Additionally, it has shown promise in modulating immune responses, making it a candidate for combination therapies in cancer treatment. The compound is typically studied in preclinical models to evaluate its efficacy and safety profile. Its solubility, stability, and pharmacokinetic properties are also important factors that influence its potential therapeutic applications. Overall, WP1066 represents a significant area of interest in the development of targeted cancer therapies.

Formula: C₁₇H₁₄BrN₃O

Synonyms:

• WP1066, 98%, a novel inhibitor of JAK2 and STAT3
• WP1066 USP/EP/BP
• Stat3 Inhibitor III, WP1066
• WP1066
• WP1066/WP-1066
• WP1066, >=99%
• (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
• 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-, (2E)-
• (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066
• WP1066; WP 1066;WP-1066
• STAT Inhibitor III
• wp1066(STAT Inhibitor III)
• (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
• (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide

WP1066

CAS: 857064-38-1

Formula: C₁₇H₁₄BrN₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 356.2166

Ref: IN-DA004ZLR

(S,E)-3-(6-Bromopyridin-2-Yl)-2-Cyano-N-(1-Phenylethyl)Acrylamide

CAS: 857064-38-1

(S,E)-3-(6-Bromopyridin-2-Yl)-2-Cyano-N-(1-Phenylethyl)Acrylamide

Purity: 98%

Molecular weight: 356.22g/mol

Ref: 54-OR1025714

WP1066

CAS: 857064-38-1

WP1066

Purity: ≥98%

Molecular weight: 356.22g/mol

Ref: 54-BUP13480

WP1066

CAS: 857064-38-1

WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.

Formula: C₁₇H₁₄BrN₃O

Purity: 98.92% - 99.73%

Color and Shape: Solid

Molecular weight: 356.22

Ref: TM-T2156

(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide

CAS: 857064-38-1

(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide (MBI-23) is a potential antineoplastic agent that has been shown to induce regression of bladder cancer in mice. MBI-23 induces apoptosis by inhibiting the proliferation of cancer cells and inducing differentiation of cancer stem cells. It is also shown to inhibit tumor growth and progression in glioma and prostate cancer models. MBI-23 binds to the KDR receptor subtype, which is activated by organic acids and inhibited by inorganic compounds. This binding leads to constitutive activation of the KDR receptor, thereby inducing apoptosis. The tautomers and stereoisomers of MBI-23 have not been fully elucidated yet.

Formula: C₁₇H₁₄ON₃Br

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 356.22 g/mol

Ref: 3D-FB34118

(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide

CAS: 857064-38-1

Formula: C₁₇H₁₄BrN₃O

Purity: 98%

Color and Shape: Solid, solid

Molecular weight: 356.223

Ref: 10-F234436

WP1066

Controlled Product

CAS: 857064-38-1

Applications WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells.
References Iwamura, A., et al.: Oncogene., 26, 2435 (2007)

Formula: C₁₇H₁₄BrN₃O

Color and Shape: Neat

Molecular weight: 356.22

Ref: TR-W499500