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CAS 857402-23-4

:

Retaspimycin

Description:
Retaspimycin, with the CAS number 857402-23-4, is a small molecule that functions primarily as a heat shock protein 90 (HSP90) inhibitor. It is part of a class of compounds that target the HSP90 chaperone, which plays a crucial role in the proper folding and stabilization of various client proteins involved in cancer progression and survival. By inhibiting HSP90, retaspimycin disrupts the function of these client proteins, leading to cancer cell apoptosis and reduced tumor growth. The compound has shown potential in preclinical studies for treating various types of cancer, including solid tumors and hematological malignancies. Retaspimycin is typically characterized by its specific molecular structure, which includes a core that allows it to effectively bind to the HSP90 protein. Its pharmacological profile includes considerations of solubility, bioavailability, and metabolic stability, which are critical for its therapeutic application. Ongoing research continues to explore its efficacy and safety in clinical settings, as well as potential combinations with other therapeutic agents.
Formula:C31H45N3O8
InChI:InChI=1S/C31H45N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,35-37H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
InChI key:InChIKey=OAKGNIRUXAZDQF-TXHRRWQRSA-N
SMILES:N(CC=C)C1=C2C(O)=C(C=C1O)NC(=O)\C(\C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(\C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2
Synonyms:
  • 17 AAGH<sub>2</sub>
  • 18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)geldanamycin
  • 18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)geldanamycin
  • Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-
  • Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-
  • Retaspimycin
  • 17 AAGH2
  • Unii-bzf2zm0I5z
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Found 2 products.