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CAS 857402-63-2

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Retaspimycin hydrochloride

Description:
Retaspimycin hydrochloride is a small molecule inhibitor primarily known for its role as a heat shock protein 90 (HSP90) inhibitor. It is classified as a synthetic compound and is often investigated for its potential therapeutic applications in cancer treatment due to its ability to disrupt the function of HSP90, which is crucial for the stability and activity of various oncogenic proteins. The hydrochloride salt form enhances its solubility and bioavailability. Retaspimycin hydrochloride exhibits a moderate to high affinity for HSP90, leading to the degradation of client proteins involved in tumor growth and survival. Its mechanism of action involves the inhibition of the chaperone activity of HSP90, resulting in the destabilization of multiple signaling pathways that are often upregulated in cancer cells. Additionally, it has been studied in combination with other therapeutic agents to enhance anticancer efficacy. As with many investigational drugs, the pharmacokinetics, safety profile, and specific therapeutic indications are subjects of ongoing research.
Formula:C31H45N3O8·ClH
InChI:InChI=1S/C31H45N3O8.ClH/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35;/h8-11,15-17,19,24-25,27,29,33,35-37H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38);1H/b11-9-,18-10+,20-15+;/t17-,19+,24+,25+,27-,29+;/m1./s1
InChI key:InChIKey=OIRUWDYJGMHDHJ-AFXVCOSJSA-N
SMILES:N(CC=C)C1=C2C(O)=C(C=C1O)NC(=O)/C(/C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)\C(\C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2.Cl
Synonyms:
  • Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-, hydrochloride (1:1)
  • Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride
  • Ip 504
  • Ipi 504
  • Retaspimycin hydrochloride
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