CAS 85754-59-2

Ambamustine

Description:

Ambamustine, with the CAS number 85754-59-2, is a synthetic alkylating agent that belongs to the class of compounds known as nitrogen mustards. It is primarily characterized by its ability to form covalent bonds with DNA, leading to cross-linking and subsequent inhibition of DNA replication and transcription. This mechanism makes it a potential chemotherapeutic agent, particularly in the treatment of certain types of cancers. Ambamustine exhibits a unique structure that combines features of both alkylating agents and other therapeutic modalities, which may enhance its efficacy and reduce side effects compared to traditional chemotherapeutics. Its solubility, stability, and reactivity are influenced by its chemical structure, which includes a chloroethyl group that is crucial for its biological activity. Research into Ambamustine's pharmacokinetics, toxicity, and therapeutic window is ongoing, as it holds promise for improving cancer treatment outcomes. However, as with many alkylating agents, careful consideration of its potential side effects and mechanisms of resistance is essential in clinical applications.

Formula: C₂₉H₃₉Cl₂FN₄O₄S

InChI: InChI=1/C29H39Cl2FN4O4S/c1-3-40-29(39)25(11-16-41-2)34-28(38)26(35-27(37)24(33)18-20-7-9-22(32)10-8-20)19-21-5-4-6-23(17-21)36(14-12-30)15-13-31/h4-10,17,24-26H,3,11-16,18-19,33H2,1-2H3,(H,34,38)(H,35,37)/t24-,25-,26-/m0/s1

Synonyms:

• UNII-IB1H345F24
• Ambamustine [INN]
• N-(3-(m-(Bis(2-chloroethyl)amino)phenyl)-N-(3-(p-fluorophenyl)-L-alanyl)-L-alanyl)-L-methionine, ethyl ester
• ethyl 4-fluoro-L-phenylalanyl-3-[bis(2-chloroethyl)amino]-L-phenylalanyl-L-methioninate
• L-Methionine, 4-fluoro-L-phenylalanyl-3-[bis(2-chloroethyl)amino]-L-phenylalanyl-, ethyl ester
• Ambamustine
• Ambamustine USP/EP/BP

Ambamustine

CAS: 85754-59-2

Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.

Formula: C₂₉H₃₉Cl₂FN₄O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 629.61

Ref: TM-T25073