CAS 857758-90-8

4-(Trifluoromethyl)-8-quinolinamine

Description:

4-(Trifluoromethyl)-8-quinolinamine, with the CAS number 857758-90-8, is an organic compound characterized by its quinoline structure, which consists of a bicyclic aromatic system. The presence of a trifluoromethyl group (-CF3) at the 4-position and an amino group (-NH2) at the 8-position significantly influences its chemical properties and reactivity. This compound is typically a solid at room temperature and may exhibit moderate solubility in polar organic solvents. The trifluoromethyl group enhances the lipophilicity and metabolic stability of the molecule, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. Additionally, the amino group can participate in hydrogen bonding, affecting the compound's interactions with biological targets. The compound's unique electronic properties, derived from the electron-withdrawing trifluoromethyl group, can also influence its reactivity in various chemical reactions, including nucleophilic substitutions and coupling reactions. Overall, 4-(Trifluoromethyl)-8-quinolinamine is a versatile compound with potential applications in drug discovery and development.

Formula: C₁₀H₇F₃N₂

InChI: InChI=1S/C10H7F3N2/c11-10(12,13)7-4-5-15-9-6(7)2-1-3-8(9)14/h1-5H,14H2

InChI key: InChIKey=ASJWQBTUQNJIQQ-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C=1C2=C(C(N)=CC=C2)N=CC1

Synonyms:

• Quinoline, 8-amino-4-(trifluoromethyl)-
• 8-Quinolinamine, 4-(trifluoromethyl)-
• 4-(Trifluoromethyl)-8-quinolinamine