CAS 85797-13-3

2-Amino-7-phosphonoheptanoic acid

Description:

2-Amino-7-phosphonoheptanoic acid, commonly referred to as AP7, is a synthetic amino acid derivative that serves as a selective antagonist of the NMDA (N-methyl-D-aspartate) receptor, which is crucial in neurotransmission and synaptic plasticity in the central nervous system. This compound features a heptanoic acid backbone with an amino group and a phosphono group, contributing to its unique properties. AP7 is characterized by its ability to inhibit excitatory neurotransmission, making it a valuable tool in neuropharmacological research, particularly in studies related to neurodegenerative diseases and cognitive functions. The presence of the phosphono group enhances its stability and solubility in biological systems. Additionally, AP7 has been investigated for its potential therapeutic applications in conditions such as stroke, Alzheimer's disease, and other neurological disorders. Its specific interactions with NMDA receptors allow for a nuanced modulation of synaptic activity, highlighting its importance in both basic research and potential clinical applications.

Formula: C₇H₁₆NO₅P

InChI: InChI=1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)

InChI key: InChIKey=MYDMWESTDPJANS-UHFFFAOYSA-N

SMILES: C(CC(C(O)=O)N)CCCP(=O)(O)O

Synonyms:

• (±)-2-Amino-7-phosphonoheptanoic acid
• Heptanoic acid, 2-amino-7-phosphono-
• AP 7
• 2-APH
• 2-Amino-7-phosphonoheptanoic acid
• 2-amino-7-phosphono-heptanoicaci
• (+/-)-2-AMINO-7-PHOSPHONOHEPTANOIC
• Brn 3544152

DL-2-Amino-7-phosphonoheptanoic acid

CAS: 85797-13-3

Formula: C₇H₁₆NO₅P

Molecular weight: 225.18

Ref: 7W-GL5296

DL-AP7

CAS: 85797-13-3

DL-AP7: competitive NMDA antagonist, anticonvulsant, inhibits NMDA convulsions, impairs mice learning.

Formula: C₇H₁₆NO₅P

Purity: 98%

Color and Shape: Solid

Molecular weight: 225.18

Ref: TM-T22734

DL-AP7

CAS: 85797-13-3

DL-AP7 is a synthetic compound that has been shown to act as a non-competitive receptor antagonist at the benzodiazepine site of the GABAA receptor. DL-AP7 has been shown to increase energy metabolism in the brain and to inhibit locomotor activity in rats. It also inhibits protein synthesis and cardiac effects induced by estradiol benzoate, an endogenous substance. DL-AP7 binds with high affinity to receptors in the hippocampal formation, occipital cortex, and other areas of the brain. This drug has been shown to bind competitively to dopamine D2 receptors and inhibit neurotransmission by binding to GABA receptors in rat brains.

Formula: C₇H₁₆NO₅P

Purity: Min. 95%

Molecular weight: 225.18 g/mol

Ref: 3D-KDA79713