CAS 85798-08-9

(-)-Quinpirole hydrochloride

Description:

(-)-Quinpirole hydrochloride is a chemical compound that belongs to the class of quinoline derivatives and is primarily recognized for its role as a selective dopamine D2 receptor agonist. This compound is often utilized in pharmacological research, particularly in studies related to neuropharmacology and behavioral science, due to its ability to mimic the effects of dopamine in the central nervous system. The hydrochloride salt form enhances its solubility in water, making it suitable for various experimental applications. (-)-Quinpirole is characterized by its chiral nature, with the "(-)" designation indicating its specific stereochemistry, which is crucial for its biological activity. The compound is typically administered in research settings to investigate its effects on locomotion, reward pathways, and other dopaminergic functions. Safety and handling precautions are essential when working with this substance, as it can have significant effects on the nervous system. Overall, (-)-Quinpirole hydrochloride serves as an important tool in understanding dopamine-related processes and potential therapeutic targets for neurological disorders.

Formula: C₁₃H₂₂ClN₃

InChI: InChI=1/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1

InChI key: InChIKey=HJHVRVJTYPKTHX-HTMVYDOJSA-N

SMILES: C(CC)N1[C@]2([C@@](CC3=C(C2)C=NN3)(CCC1)[H])[H].Cl

Synonyms:

• (-)-(4aR,8aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo(3,4-g)quinoline monohydrochloride
• (4aR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline
• 1H-Pyrazolo(3,4-g)quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, monohydrochloride, (4aR-trans)-
• 1H-Pyrazolo[3,4-g]quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, hydrochloride (1:1), (4aR,8aR)-
• 1H-Pyrazolo[3,4-g]quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, monohydrochloride, (4aR,8aR)-
• 4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline
• Ly 171555
• Quinpirole HCl
• Quinpirole hydrochloride [USAN]
• Unii-T6I2W5V2K1
• Quinpirole hydrochloride
• Quinpirole hydrochloride
• (-)-quinpirole monohydrochloride
• TRANS-(-)-4AR-4,4A,5,6,7,8,8A,9-OCTAHYDRO-5-PROPYL-1H-PYRAZOLO[3,4-G] QUINOLINE HYDROCHLORIDE
• trans-(–)-(4aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline monohydrochloride
• (-)-QUINPIROLE HYDROCHLORIDE (LY-171555) SELECTIVE D2 DOPAMINE
• (4ar-trans)-lorid
• (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline:hydrochloride
• ()-Quinpirole
• (4AR-TRANS)-4,4A,5,6,7,8,8A,9-OCTAHYDRO-5-PROPYL-1H-PYRAZOLO[3,4-G]QUINOLINE HYDROCHLORIDE

(4AR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline hydrochloride

CAS: 85798-08-9

Formula: C₁₃H₂₂ClN₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 255.7869

Ref: IN-DA004XX9

(-)-Quinpirole hydrochloride

CAS: 85798-08-9

Formula: C₁₃H₂₁N₃·HCl

Molecular weight: 255.79

Ref: 7W-GL8490

(-)-Quinpirole Hydrochloride

Controlled Product

CAS: 85798-08-9

Applications (-)-Quinpirole Hydrochloride is a selective dopamine D2 receptor agonist (1). It has a high affinity for the D2 and D3 dopamine receptor subtypes. (-)-Quinpirole Hydrochloride has been utilized to investigate Parkinson's disease-like pathology in Drosophila melanogaster (2).
References (1) Huang, Y., et al.: Neuro Endocrinol Lett. 37, 491 (2016) (2) Wiemerslage, L., et al.: J Neurochem. 126, 529 (2013)

Formula: C₁₃H₂₁N₃·(HCl)

Color and Shape: White To Off-White

Molecular weight: 219.33 + (36.46)

Ref: TR-Q796713

Quinpirole Hydrochloride

CAS: 85798-08-9

Quinpirole Hydrochloride (LY 171555), as an agonist with high affinity for dopamine receptor D2/D3, has been widely used to study the function of dopamine receptor D2/D3 in humans and mice

Formula: C₁₃H₂₂ClN₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 255.79

Ref: TM-T12606