CAS 858517-21-2

2H-Naphth[1,2-b]-1,4-oxazin-9-ol,3,4,4a,5,6,10b-hexahydro-, hydrochloride (1:1), (4aR,10bR)-

Description:

2H-Naphth[1,2-b]-1,4-oxazin-9-ol,3,4,4a,5,6,10b-hexahydro-, hydrochloride (1:1), (4aR,10bR)- is a chemical compound characterized by its complex bicyclic structure, which includes a naphthalene moiety fused to an oxazine ring. This compound features multiple stereocenters, contributing to its specific stereochemistry, denoted by the (4aR,10bR) configuration. As a hydrochloride salt, it is typically more soluble in water compared to its free base form, which can enhance its bioavailability in pharmaceutical applications. The presence of hydroxyl (-OH) and nitrogen-containing functional groups suggests potential interactions with biological systems, making it of interest in medicinal chemistry. Its structural features may impart specific pharmacological properties, potentially influencing its activity as a therapeutic agent. However, detailed studies on its biological activity, toxicity, and pharmacokinetics would be necessary to fully understand its applications and safety profile.

Formula: C₁₂H₁₆ClNO₂

Synonyms:

• 2H-Naphth[1,2-b]-1,4-oxazin-9-ol,3,4,4a,5,6,10b-hexahydro-, hydrochloride, (4aR,10bR)- (9CI)
• (+)-3,4,4a,5,6,10b-Hexahydro-2H-naphtho[1,2-β][1,4]oxazin-9-ol Hydrochloride
• (4aS,10bS)-3,4,4a,5,6,10b-hexahydro-2H-Naphth[1,2-β]-1,4-oxazin-9-ol, Hydrochloride
• (4aR,10bR)- 3,4,4a,5,6,10b-hexahydro-2H-Naphth[1,2-b]-1,4-oxazin-9-ol, hydrochloride
• (+)-3,4,4a,5,6,10b-Hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol
• (4aR,10bR)- 3,4,4a,5,6,10b-Hexahydro-2H-Naphth[1,2-β]-1,4-oxazin-9-ol, Hydrochloride

(+)-3,4,4a,5,6,10b-Hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol Hydrochloride

Controlled Product

CAS: 858517-21-2

Applications A dopamine agonist. This compound has been used as a precursor for the PET radiotracer, 11C-(+)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol.
References Dijkstra, D., et al.: J. Med. Chem., 45, 3022 (2002), Wilson, A.A. et al.: J. Med. Chem., 48, 4153 (2005)

Formula: C₁₂H₁₅NO₂·ClH

Color and Shape: Neat

Molecular weight: 241.71

Ref: TR-H294075