CAS 859-18-7

Lincomycin hydrochloride

Description:

Lincomycin hydrochloride is an antibiotic that belongs to the lincosamide class of antibiotics, primarily used to treat various bacterial infections. It is derived from the bacterium *Streptomyces lincolnensis*. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for parenteral administration. Lincomycin hydrochloride works by inhibiting bacterial protein synthesis, effectively targeting Gram-positive bacteria and some anaerobic organisms. Its mechanism of action involves binding to the 50S subunit of the bacterial ribosome, thereby preventing the elongation of peptide chains during translation. Clinically, it is often used for treating infections of the skin, respiratory tract, and soft tissues, particularly in patients who are allergic to penicillin. However, it is essential to monitor for potential side effects, including gastrointestinal disturbances and the risk of Clostridium difficile-associated diarrhea. As with all antibiotics, appropriate susceptibility testing is recommended to ensure efficacy against the specific bacterial strain being treated.

Formula: C₁₈H₃₄N₂O₆S·ClH

InChI: InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

InChI key: InChIKey=POUMFISTNHIPTI-BOMBIWCESA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@@H](C)O)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H].Cl

Synonyms:

• <span class="text-smallcaps">D</smallcap>-erythro-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-α-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride
• Lincocin
• Lincogap
• Lincomix
• Lincomycin Hcl
• Lincomycin Hydrochloride
• Lincomycin hydrochloride anhydrous
• NSC 70731
• U 10149a
• hydrogen chloride methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-gluco-octopyranoside (1:1:1)
• methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride
• methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
• D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-α-

Lincomycin Hydrochloride Monohydrate

CAS: 154-21-2, 7179-49-9, 859-18-7

Formula: C₁₈H₃₄N₂O₆S·HCl·H₂O

Purity: >98.0%(T)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 461.02

Ref: 3B-L0166

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride (HCl), 859-18-7, is the salt form of lincomycin, a lincosamide antibiotic which exhibits activity against gram-positive bacteria. Learn more.

Formula: C₁₈H₃₅ClN₂O₆S

Color and Shape: White, Crystalline Powder

Molecular weight: 443.00

Ref: 02-J61251

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride

Formula: C₁₈H₃₄N₂O₆S

Purity: 86.9%

Color and Shape: White

Molecular weight: 406.21376

Ref: 47-215

D-erythro-a-D-galacto-Octopyranoside, methyl6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride

CAS: 859-18-7

Formula: C₁₈H₃₅ClN₂O₆S

Purity: 95%

Color and Shape: Solid

Molecular weight: 442.9983

Ref: IN-DA00IDT6

Lincomycin hydrochloride, EP grade

CAS: 859-18-7

Formula: C₁₈H₃₄N₂O₆S·HCl·xH₂O

Purity: 96.0 - 102.0 % (Lincomycin hydrochloride + Lincomycin B hydrochloride (anhydrous basis))

Color and Shape: White or almost white crystalline powder

Molecular weight: 443.00 (anhydrous)

Ref: 7W-GP0215

Lincomycin hydrochloride

CAS: 859-18-7

Formula: C₁₈H₃₄N₂O₆S·HCl·xH₂O

Purity: 90.0 - 102.0 % (C18H35ClN2O6S, anhydrous basis)

Color and Shape: White or almost white crystalline powder

Molecular weight: 443.00 (anhydrous)

Ref: 7W-GA3892

Lincomycin HCl (Clindamycin Phosphate EP Impurity A HCl)

CAS: 859-18-7

Formula: C₁₈H₃₄N₂O₆S·HCl

Molecular weight: 406.54 36.46

Ref: 4Z-L-093013

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride

Purity: ≥95%

Molecular weight: 443g/mol

Ref: 54-BUP16885

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride (U10149A) is a lincosamide antibiotic identified in S.lincolnensis with activity against gram-positive cocci and anaerobic bacteria.

Formula: C₁₈H₃₄N₂O₆S·HCl

Purity: 97% - >99.99%

Color and Shape: Crystalline

Molecular weight: 443

Ref: TM-T1277

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride

Purity: 90%

Color and Shape: Solid

Molecular weight: 443.00g/mol

Ref: 54-BIL0127

Lincomycin Hydrochloride Monohydrate

Controlled Product

CAS: 7179-49-9, 859-18-7

Formula: C₁₈H₃₄N₂O₆SClHH₂O

Color and Shape: Neat

Molecular weight: 461.01

Ref: 86-MM0320.00

Lincomycin Hydrochloride

Controlled Product

CAS: 859-18-7

Applications An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),

Formula: C₁₈H₃₄N₂O₆S·ClH

Color and Shape: White To Off-White

Molecular weight: 443.00

Ref: TR-L466200

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin is active against gram-positive bacteria such as staphylococci, streptococci, pneumococci, diphtheria bacillus, and clostridia. It is used to treat severe bacterial infections including: sepsis, osteomyelitis, septic endocarditis, pneumonia, pulmonary abscess, infected wounds, purulent meningitis and severe pseudomembranous colitis. Lincomycin is an alternative antibiotic for penicillin-resistant gram-positive bacteria.

Formula: C₁₈H₃₅ClN₂O₆S

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 443 g/mol

Ref: 3D-AL16775