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CAS 85916-84-3

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Methimazole

Description:
Methimazole is an antithyroid medication primarily used to treat hyperthyroidism, particularly in conditions like Graves' disease. It functions by inhibiting the enzyme thyroid peroxidase, which is crucial for the synthesis of thyroid hormones. This action reduces the production of thyroxine (T4) and triiodothyronine (T3), helping to manage symptoms associated with excessive thyroid hormone levels. Methimazole is typically administered orally and is known for its relatively rapid onset of action. The substance is characterized by its chemical formula C4H6N2S, and it appears as a white to off-white crystalline powder. Methimazole is soluble in water and has a moderate molecular weight. Common side effects may include rash, gastrointestinal disturbances, and, in rare cases, agranulocytosis, a potentially serious decrease in white blood cell count. Due to its mechanism of action, methimazole is contraindicated in patients with certain types of thyroid dysfunction and should be used with caution in pregnant or breastfeeding women. Regular monitoring of thyroid function is essential during treatment.
Formula:C4H6N2S
InChI:InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChI key:InChIKey=PMRYVIKBURPHAH-UHFFFAOYSA-N
SMILES:S=C1N(C)C=CN1
Synonyms:
  • 4-Imidazoline-2-thione, 1-methyl-
  • 1,3-Dihydro-1-methyl-2H-imidazole-2-thione
  • Imidazole-2-thiol, 1-methyl-
  • 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-
  • Basolan
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