CAS 859209-74-8

N,N′-[[[2-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy]methyl]phosphinylidene]bis[L-alanine] 1,1′-ethyl ester

Description:

N,N′-[[[2-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy]methyl]phosphinylidene]bis[L-alanine] 1,1′-ethyl ester, identified by its CAS number 859209-74-8, is a complex organic compound characterized by its unique structural features, which include a purine base, an ethoxy group, and a phosphinylidene moiety. This compound is notable for its potential biological activity, particularly in the realm of medicinal chemistry, where it may exhibit properties relevant to therapeutic applications. The presence of the cyclopropylamino group suggests possible interactions with biological targets, enhancing its pharmacological profile. Additionally, the bis-L-alanine component indicates that it may participate in peptide-like interactions, potentially influencing its solubility and stability in biological systems. The ethyl ester functionality can also affect the compound's lipophilicity, impacting its absorption and distribution in vivo. Overall, this compound represents a fascinating area of study for researchers interested in drug design and development, particularly in the context of nucleoside analogs and their derivatives.

Formula: C₂₁H₃₅N₈O₆P

InChI: InChI=1S/C21H35N8O6P/c1-5-34-19(30)13(3)27-36(32,28-14(4)20(31)35-6-2)12-33-10-9-29-11-23-16-17(24-15-7-8-15)25-21(22)26-18(16)29/h11,13-15H,5-10,12H2,1-4H3,(H2,27,28,32)(H3,22,24,25,26)/t13-,14-/m0/s1

InChI key: InChIKey=ANSPEDQTHURSFQ-KBPBESRZSA-N

SMILES: C(COCP(N[C@H](C(OCC)=O)C)(N[C@H](C(OCC)=O)C)=O)N1C=2C(=C(NC3CC3)N=C(N)N2)N=C1

Synonyms:

• L-Alanine, N,N′-[[[2-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy]methyl]phosphinylidene]bis-, diethyl ester
• GS 9219
• N,N′-[[[2-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy]methyl]phosphinylidene]bis[L-alanine] 1,1′-ethyl ester
• L-Alanine, N,N′-[[[2-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy]methyl]phosphinylidene]bis-, 1,1′-ethyl ester
• VDC 1101

Rabacfosadine

CAS: 859209-74-8

Rabacfosadine

Purity: ≥98%

Molecular weight: 526.53g/mol

Ref: 54-BUP09244

Rabacfosadine

CAS: 859209-74-8

Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma.

Formula: C₂₁H₃₅N₈O₆P

Purity: 99.06% - 99.37%

Color and Shape: Solid

Molecular weight: 526.53

Ref: TM-T16716

Rabacfosadine

CAS: 859209-74-8

Rabacfosadine is a novel antiviral drug that has been shown to be effective in the treatment of HIV. It is a potent inhibitor of viral DNA synthesis and viral replication, which are essential for the production of new viruses. Rabacfosadine has also been shown to have antitumor activity against human cancer cells. This drug inhibits collagen production and causes cell death by apoptosis, which may lead to its use as an anti-inflammatory drug. Rabacfosadine blocks viral DNA synthesis and replication by inhibiting the enzyme DNA polymerase, preventing the production of new viruses. The clinical response of rabacfosadine to HIV treatment is statistically significant with a number of clinical trials showing positive results. Rabacfosadine is also used in the treatment of herpes simplex virus infections and lymphocytic leukemia. Chronic lymphocytic leukemia patients are given rabacfosadine as part of their chemotherapy regimen, along with tenofovir

Formula: C₂₁H₃₅N₈O₆P

Purity: Min. 95%

Molecular weight: 526.5 g/mol

Ref: 3D-JJB20974