CAS 86-42-0

Amodiaquine

Description:

Amodiaquine is an antimalarial drug that belongs to the 4-aminoquinoline class, closely related to chloroquine. It is primarily used for the treatment and prevention of malaria, particularly in areas where resistance to other antimalarial medications is prevalent. The chemical formula of amodiaquine is C18H20ClN3O, and it features a chloro group, a piperidine ring, and an amino group, contributing to its pharmacological activity. Amodiaquine exhibits a mechanism of action similar to that of chloroquine, interfering with the heme detoxification process in the malaria parasite, ultimately leading to its death. The substance is typically administered in its hydrochloride salt form, which enhances its solubility. While effective, amodiaquine can have side effects, including gastrointestinal disturbances and potential hematological issues, such as agranulocytosis. Due to its safety profile and the emergence of resistance, its use has become more limited in recent years, with healthcare providers often opting for alternative treatments.

Formula: C₂₀H₂₂ClN₃O

InChI: InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)

InChI key: InChIKey=OVCDSSHSILBFBN-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(Cl)C=C2)N=CC1)C3=CC(CN(CC)CC)=C(O)C=C3

Synonyms:

• 4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol
• 7-Chloro-4-(3-diethylaminomethyl-4-hydroxyanilino)quinoline
• Amodiachin
• Amodiaquin
• Amodiaquina
• Amodiaquine
• Cam-Aq 1
• Cam-Aqi
• Camochin
• Camoquin
• Camoquinal
• Camoquine
• Flavoquine
• Miaquin
• Nsc 13453
• Quinoline, 7-chloro-4-[[3-[(diethylamino)methyl]-4-hydroxyphenyl]amino]-
• Sn 10,751
• Sunoquine
• o-Cresol, 4-[(7-chloro-4-quinolyl)amino]-α-(diethylamino)-
• Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-

Amodiaquine Dihydrochloride Dihydrate

CAS: 6398-98-7, 69-44-3, 86-42-0

Formula: C₂₀H₂₂ClN₃O·2HCl·2H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 464.81

Ref: 3B-A3133

Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-

CAS: 86-42-0

Formula: C₂₀H₂₂ClN₃O

Purity: %

Color and Shape: Solid

Molecular weight: 355.8612

Ref: IN-DA01CBSM

Amodiaquine

CAS: 86-42-0

Amodiaquine

Purity: ≥98%

Molecular weight: 355.86g/mol

Ref: 54-BUP04688

Amodiaquine

CAS: 86-42-0

Amodiaquine is a synthetic aminoquinoline, used to treat malaria.

Formula: C₂₀H₂₂ClN₃O

Purity: 99.78% - 99.99%

Color and Shape: Crystals From Absolute Ethanol Solid

Molecular weight: 355.86

Ref: TM-T8381

Amodiaquine

Controlled Product

CAS: 86-42-0

Formula: C₂₀H₂₂ClN₃O

Color and Shape: Light Yellow

Molecular weight: 355.86

Ref: TR-A634200

Amodiaquine

CAS: 86-42-0

Amodiaquine is a drug that belongs to the class of antimalarial agents. It is used for the treatment and prevention of malaria caused by erythrocytic forms of Plasmodium falciparum. Amodiaquine has shown synergistic effects with other drugs, such as sulfadoxine and pyrimethamine, for the treatment of malaria due to P. falciparum. The mechanism of action of amodiaquine is not well understood, but it may involve inhibition of the Toll-like receptor. Amodiaquine has been shown to inhibit polymerase chain reaction in a concentration-dependent manner and also inhibits polymorphonuclear leucocytes, which are important in innate immunity. In addition, amodiaquine is a hypoglycemic agent and can be used for the treatment of bowel disease.

Formula: C₂₀H₂₂ClN₃O

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 355.86 g/mol

Ref: 3D-FC17879