CAS 860005-21-6

Latanoprostene bunod

Description:

Latanoprostene bunod is a synthetic compound primarily used in ophthalmology for the treatment of glaucoma and ocular hypertension. It is a prodrug of latanoprost, which is a prostaglandin analog that facilitates the reduction of intraocular pressure by increasing the outflow of aqueous humor. The compound features a unique structure that includes a butanamide moiety, which enhances its pharmacological properties. Latanoprostene bunod is characterized by its ability to release nitric oxide, contributing to its efficacy in lowering intraocular pressure. This dual mechanism of action—both through prostaglandin pathways and nitric oxide release—distinguishes it from other treatments. The substance is typically administered as an eye drop formulation, and its safety profile is generally favorable, with common side effects including conjunctival hyperemia and changes in iris pigmentation. Overall, latanoprostene bunod represents a significant advancement in glaucoma therapy, offering a novel approach to managing intraocular pressure.

Formula: C₂₇H₄₁NO₈

InChI: InChI=1S/C27H41NO8/c29-22(15-14-21-10-4-3-5-11-21)16-17-24-23(25(30)20-26(24)31)12-6-1-2-7-13-27(32)35-18-8-9-19-36-28(33)34/h1,3-6,10-11,22-26,29-31H,2,7-9,12-20H2/b6-1-/t22-,23+,24+,25-,26+/m0/s1

InChI key: InChIKey=LOVMMUBRQUFEAH-UIEAZXIASA-N

SMILES: C(C[C@H](CCC1=CC=CC=C1)O)[C@@H]2[C@@H](C/C=C\CCCC(OCCCCON(=O)=O)=O)[C@@H](O)C[C@H]2O

Synonyms:

• Vyzulta
• Vesneo
• Latanoprostene bunod
• NCX 116
• 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, 4-(nitrooxy)butyl ester, (5Z)-

Latanoprostene bunod

CAS: 860005-21-6

LBN is a NO-donating prostaglandin analog for reducing IOP in glaucoma or OHT patients.

Formula: C₂₇H₄₁NO₈

Purity: 99.33% - 99.69%

Color and Shape: Solid

Molecular weight: 507.62

Ref: TM-T15719

Latanoprostene Bunod

CAS: 860005-21-6

Formula: C₂₇H₄₁NO₈

Color and Shape: Colorless Liquid

Molecular weight: 507.62

Ref: 4Z-L-3226

Latanoprostene Bunod

CAS: 860005-21-6

Formula: C₂₇H₄₁NO₈

Molecular weight: 507.62

Ref: ST-EA-CP-L32023

Latanoprostene Bunod

CAS: 860005-21-6

Stability Hygroscopic, Temperature Sensitive
Applications Latanoprostene Bunod is a derivative of Latanoprost and is used in the treatment of interocular pressure.
References Kaufman, P. et al.: Exp. Opinion. Pharmacother., 18, 433 (2017); Liu, J. et al.: Am.J. Ophthal., 169, 249 (2016);

Formula: C₂₇H₄₁NO₈

Color and Shape: Colourless To Light Yellow

Molecular weight: 507.62

Ref: TR-L177335