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CAS 86002-90-6

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18-Hydroxycortisol

Description:
18-Hydroxycortisol is a steroid hormone that is a derivative of cortisol, primarily produced in the adrenal glands. It is classified as a glucocorticoid and plays a role in the regulation of various physiological processes, including metabolism and immune response. The chemical structure of 18-Hydroxycortisol features a hydroxyl group at the 18th carbon position, which distinguishes it from cortisol. This compound is involved in the biosynthesis of aldosterone and is a key intermediate in the adrenal steroidogenesis pathway. It is typically measured in clinical settings to assess adrenal function and diagnose conditions such as congenital adrenal hyperplasia or adrenal tumors. The substance is also of interest in research related to stress response and metabolic disorders. Due to its biological activity, 18-Hydroxycortisol can influence electrolyte balance and blood pressure regulation. As with many steroid hormones, its levels in the body can be affected by various factors, including stress, illness, and hormonal imbalances.
Formula:C21H30O6
InChI:InChI=1S/C21H30O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21-/m0/s1
InChI key:InChIKey=HESFZGWRDUVOMS-UKSDXMLSSA-N
SMILES:C(O)[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]
Synonyms:
  • Pregn-4-ene-3,20-dione, 11,17,18,21-tetrahydroxy-, (11β)-
  • (11β)-11,17,18,21-Tetrahydroxypregn-4-ene-3,20-dione
  • 4-Pregnene-11β,17,18,21-tetrol-3,20-dione
  • 18-Hydroxycortisol
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