CAS 86060-86-8

fmoc-L-alanine pentafluorophenyl ester

Description:

Fmoc-L-alanine pentafluorophenyl ester is a chemical compound commonly used in peptide synthesis and organic chemistry. It features the Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which is widely utilized to protect amino groups during peptide formation. The presence of the pentafluorophenyl ester moiety enhances the reactivity of the carboxylic acid, facilitating the formation of peptide bonds. This compound is typically a white to off-white solid and is soluble in organic solvents such as dichloromethane and dimethylformamide. Its structure includes a phenyl ring substituted with five fluorine atoms, which contributes to its unique chemical properties, including increased lipophilicity and stability. Fmoc-L-alanine pentafluorophenyl ester is valued for its ability to provide selective protection and activation of amino acids, making it a crucial reagent in the synthesis of peptides and other complex organic molecules. Proper handling and storage are essential, as with many fluorinated compounds, due to potential toxicity and environmental concerns.

Formula: C₂₄H₁₆F₅NO₄

InChI: InChI=1/C24H16F5NO4/c1-11(23(31)34-22-20(28)18(26)17(25)19(27)21(22)29)30-24(32)33-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16H,10H2,1H3,(H,30,32)/t11-/m0/s1

SMILES: C[C@@H](C(=O)Oc1c(c(c(c(c1F)F)F)F)F)N=C(O)OCC1c2ccccc2c2ccccc12

Synonyms:

• Fmoc-Ala-OPfp
• N-alpha-(9-fluorenylmethyloxycarbonyl)-L-alanine pentafluorphenyl ester
• pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alaninate

Fmoc-Ala-OPfp

CAS: 86060-86-8

Bachem ID: 4011871.

Formula: C₂₄H₁₆F₅NO₄

Purity: 99.7%

Color and Shape: White

Molecular weight: 477.39

Ref: 01-4011871

Fmoc-Ala-Opfp

CAS: 86060-86-8

Formula: C₂₄H₁₆F₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 477.3802

Ref: IN-DA004UBL

Fmoc-Ala-OPfp

CAS: 86060-86-8

Molecular weight: 477.38

Ref: 7W-GM3339

Fmoc-Ala-OPfp

CAS: 86060-86-8

Fmoc-Ala-OPfp

Purity: 97%

Molecular weight: 477.38g/mol

Ref: 54-PC48020

Fmoc-L-alanine pentafluorophenyl ester

CAS: 86060-86-8

Fmoc-L-alanine pentafluorophenyl ester is a drug that inhibits the growth of microorganisms by inhibiting the synthesis of folic acid. It is used to treat patients with drug-resistant bacteria, such as Mycobacterium tuberculosis, and has shown toxic effects on human cells. Fmoc-L-alanine pentafluorophenyl ester binds to the enzyme dihydrofolate reductase and blocks the production of tetrahydrofolate, which is essential for DNA synthesis. This drug also inhibits human cells by binding to DNA gyrase in the bacterial cell wall.END>

Formula: C₂₄H₁₆F₅NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 477.38 g/mol

Ref: 3D-FF47330

fmoc-ala-opfp

CAS: 86060-86-8

Formula: C₂₄H₁₆F₅NO₄

Purity: 95.0%

Molecular weight: 477.387

Ref: 10-F045443