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CAS 86060-88-0

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fmoc-L-leucine pentafluorophenyl ester

Description:
Fmoc-L-leucine pentafluorophenyl ester is a chemical compound commonly used in peptide synthesis and other organic chemistry applications. It features the Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which is widely utilized to protect amino groups during peptide synthesis. The presence of the pentafluorophenyl ester moiety enhances the reactivity of the carboxylic acid, facilitating the formation of peptide bonds. This compound is characterized by its stability under basic conditions, making it suitable for various coupling reactions. Additionally, the pentafluorophenyl group contributes to the compound's lipophilicity and can influence solubility in organic solvents. Fmoc-L-leucine pentafluorophenyl ester is typically handled under standard laboratory conditions, and safety precautions should be observed due to the potential hazards associated with fluorinated compounds. Its applications extend beyond peptide synthesis, including use in drug development and materials science, where its unique properties can be exploited for specific chemical transformations.
Formula:C27H22F5NO4
InChI:InChI=1/C27H22F5NO4/c1-13(2)11-19(26(34)37-25-23(31)21(29)20(28)22(30)24(25)32)33-27(35)36-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,33,35)/t19-/m0/s1
SMILES:CC(C)C[C@@H](C(=O)Oc1c(c(c(c(c1F)F)F)F)F)N=C(O)OCC1c2ccccc2c2ccccc12
Synonyms:
  • Fmoc-Leu-OPfp
  • N-alpha-(9-fluorenylmethyloxycarbonyl)-L-leucine pentafluorphenyl ester
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