CAS 860642-69-9

Serlopitant

Description:

Serlopitant, identified by its CAS number 860642-69-9, is a novel chemical compound primarily recognized for its role as a selective antagonist of the neurokinin-1 (NK1) receptor. This receptor is involved in various physiological processes, including pain perception and the regulation of mood and anxiety. Serlopitant has been investigated for its potential therapeutic applications, particularly in the treatment of chronic pruritus (itching) associated with conditions like atopic dermatitis. The compound exhibits a favorable pharmacokinetic profile, allowing for effective oral administration. Its mechanism of action involves blocking the binding of substance P, a neuropeptide that activates NK1 receptors, thereby alleviating itch sensations. In clinical studies, serlopitant has shown promise in reducing itch severity and improving the quality of life for patients suffering from chronic itch. As with any pharmacological agent, ongoing research continues to evaluate its safety, efficacy, and potential side effects in diverse patient populations.

Formula: C₂₉H₂₈F₇NO₂

InChI: InChI=1S/C29H28F7NO2/c1-16(19-10-20(28(31,32)33)12-21(11-19)29(34,35)36)39-26-9-4-18-14-37(23-7-8-24(38)13-23)15-25(18)27(26)17-2-5-22(30)6-3-17/h2-3,5-6,10-13,16,18,25-27H,4,7-9,14-15H2,1H3/t16-,18-,25-,26+,27+/m1/s1

InChI key: InChIKey=FLNYCRJBCNNHRH-OIYLJQICSA-N

SMILES: O([C@H](C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@@H]2[C@H]([C@]3([C@@](CN(C3)C4=CC(=O)CC4)(CC2)[H])[H])C5=CC=C(F)C=C5

Synonyms:

• Serlopitant
• VPD737
• 3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]-2-cyclopenten-1-one
• 2-Cyclopenten-1-one, 3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]-

Serlopitant

CAS: 860642-69-9

Serlopitant is a potent and selective antagonist of the adenosine A3 receptor. It has been shown to have analgesic effects in animals, and has been used to treat chronic cough in humans. Serlopitant also binds to the neurokinin-1 receptor, which is involved in inflammatory skin diseases such as psoriasis and atopic dermatitis. Clinical studies have shown that serlopitant may be effective in treating cancer, kidney disease, and heart disease. Serlopitant is an analog of nalmefene (a drug that was previously approved for use in Europe), but it is 100 times more potent than nalmefene and does not show any affinity for opioid receptors.

Purity: Min. 95%

Ref: 3D-FS176240

Serlopitant

CAS: 860642-69-9

Serlopitant is a selective antagonist of Neurokinin-1 (NK-1) receptor.

Formula: C₂₉H₂₈F₇NO₂

Color and Shape: Solid

Molecular weight: 555.53

Ref: TM-T4533