Angiostatin is a protein fragment derived from plasminogen, known for its role as an angiogenesis inhibitor, which means it can prevent the formation of new blood vessels. This characteristic makes it a subject of interest in cancer research, as tumors often require a blood supply to grow and metastasize. Angiostatin is composed of multiple kringle domains, which are structural motifs that contribute to its stability and function. The CAS number 86090-08-6 uniquely identifies this substance in chemical databases. Angiostatin has been studied for its potential therapeutic applications, particularly in oncology, due to its ability to inhibit endothelial cell proliferation and migration. Its mechanism of action involves binding to specific receptors on endothelial cells, disrupting the signaling pathways necessary for angiogenesis. Additionally, angiostatin has shown promise in combination therapies, enhancing the efficacy of other anticancer agents. Overall, its unique properties and biological activities make angiostatin a significant focus in the development of novel cancer treatments.

Angiostatin

86090-08-6: Angiostatin is a protein fragment derived from plasminogen, known for its role as an angiogenesis inhibitor, which means it can prevent the formation of new blood vessels. This characteristic makes it a subject of interest in cancer research, as tumors often require a blood supply to grow and metastasize. Angiostatin is composed of multiple kringle domains, which are structural motifs that contribute to its stability and function. The CAS number 86090-08-6 uniquely identifies this substance in chemical databases. Angiostatin has been studied for its potential therapeutic applications, particularly in oncology, due to its ability to inhibit endothelial cell proliferation and migration. Its mechanism of action involves binding to specific receptors on endothelial cells, disrupting the signaling pathways necessary for angiogenesis. Additionally, angiostatin has shown promise in combination therapies, enhancing the efficacy of other anticancer agents. Overall, its unique properties and biological activities make angiostatin a significant focus in the development of novel cancer treatments.

Angiostatin is a potent inhibitor of new blood vessel growth, which is required for tumor growth. It is an inactive protein that has been modified to be active by attaching the enzyme thrombin to it. The immobilized Angiostatin molecule binds to calcium ions and inhibits the production of a protein that is required for cell division. This process can be used in cancer treatments to inhibit tumor growth. Porosity and molecular size are important factors when choosing an appropriate support material for immobilization.

CAS 86090-08-6

Angiostatin

Angiostatin from human plasma

Ref: 3D-LDA09008