CAS 86153-38-0

9,11-Dehydro-17α-cyanoMethyl Estradiol

Description:

9,11-Dehydro-17α-cyanoMethyl Estradiol, with the CAS number 86153-38-0, is a synthetic derivative of estradiol, a naturally occurring estrogen. This compound features modifications that enhance its pharmacological properties, making it of interest in medicinal chemistry and hormone therapy. Its structure includes a cyano group and a dehydro modification, which contribute to its unique biological activity. Typically, such compounds are studied for their potential applications in treating hormone-related conditions, including certain cancers and menopausal symptoms. The presence of the cyano group may influence its receptor binding affinity and metabolic stability. As with many synthetic estrogens, it is essential to consider its pharmacokinetics, including absorption, distribution, metabolism, and excretion, as well as its potential side effects. Safety and efficacy profiles are critical in evaluating its therapeutic use. Overall, 9,11-Dehydro-17α-cyanoMethyl Estradiol represents a significant area of research in the development of targeted hormonal therapies.

Formula: C₂₀H₂₃NO₂

Synonyms:

• 17a-Cyanomethylestra-1,3,5(10),9(11)-tetraene-3,17b-diol
• 17α-Cyanomethylestra-1,3,5(10),9(11)-tetraen-3,17β-diol
• Dienogest Impurity 3 (Dienogest EP Impurity G)
• （17α-Cyanomethylestra-1,3,5(10),9(11)-tetraen-3,17β-diol）
• [(17β)-3,17-Dihydroxyestra-1,3,5(10),9(11)-tetraen-17-yl]acetonitrile
• 19-Norpregna-1,3,5(10),9(11)-tetraene-21-nitrile, 3,17-dihydroxy-, (17α)- (9CI)
• 9,11-Dehydro-17α-cyanoMethyl Estradiol

∆9,11-Dehydro-17a-cyanomethyl Estradiol

CAS: 86153-38-0

Formula: C₂₀H₂₃NO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 309.4021

Ref: IN-DA00GXGT

Dienogest EP Impurity G

CAS: 86153-38-0

Formula: C₂₀H₂₃NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 309.41

Ref: 4Z-D-4214

∆9,11-Dehydro-17α-cyanomethyl Estradiol

Controlled Product

CAS: 86153-38-0

Applications ∆9,11-Dehydro-17α-cyanomethyl estradiol is a metabolite of progestin dienogest (D441870), and is currently being investigated for progesterone-receptor binding, progestational, antiprogestational, estrogenic and antigonadotropic activities for the inhibition of fertility. It is also being considered a novel treatment for heavy menstrual bleeding.
References Oettel, M., et al.: Pharmazie, 41, 627 (1993); Kiley, J. & Shulman, L.: Int. J. Womens Health, 3, 281 (2011);

Formula: C₂₀H₂₃NO₂

Color and Shape: Neat

Molecular weight: 309.40

Ref: TR-D229505

∆9,11-Dehydro-17α-cyanomethyl Estradiol-13C,D2

Controlled Product

CAS: 86153-38-0

Formula: CC₁₉D₂H₂₁NO₂

Color and Shape: Neat

Molecular weight: 312.407

Ref: TR-D229507

∆9,11-Dehydro-17α-cyanomethyl estradiol

Controlled Product

CAS: 86153-38-0

∆9,11-Dehydro-17α-cyanomethyl estradiol is a metabolite of chlormadinone and cyproterone acetate, which are drugs that are used in the treatment of prostate cancer. It is formed by the elimination of one hydrogen atom from the 17α position and hydroxylation of the 2α and 16β positions. The synthesis of ∆9,11-Dehydro-17α-cyanomethyl estradiol has been shown to be dependent on cytochrome P450 enzymes. This metabolite has estrogenic properties that may contribute to its activation. ∆9,11-Dehydro-17α-cyanomethyl estradiol is found in wastewater effluent as a result of drug metabolism. It can adhere to suspended solids and biofilms in wastewater treatment plants, leading to environmental risk. The rate of ∆9,11-Dehydro

Formula: C₂₀H₂₃NO₂

Purity: Min. 95%

Molecular weight: 309.4 g/mol

Ref: 3D-LDA15338

Dienogest EP Impurity G

CAS: 86153-38-0

Formula: C₂₀H₂₃NO₂

Molecular weight: 309.4

Ref: ST-EA-CP-D37007