CAS 86181-42-2

Temelastine

Description:

Temelastine, identified by its CAS number 86181-42-2, is an antihistamine that belongs to the class of compounds known as H1 receptor antagonists. It is primarily used for the treatment of allergic conditions, such as allergic rhinitis and urticaria. The substance exhibits properties that help alleviate symptoms associated with histamine release, including itching, sneezing, and runny nose. Temelastine is characterized by its ability to cross the blood-brain barrier, which may lead to central nervous system effects, although it is generally considered to have a lower sedative effect compared to first-generation antihistamines. The compound's pharmacokinetics involve oral administration, with a relatively rapid onset of action. Additionally, it is important to note that, like other antihistamines, it may have side effects, including dry mouth, dizziness, and potential interactions with other medications. Overall, Temelastine serves as a valuable therapeutic option in managing allergic symptoms, contributing to improved patient quality of life.

Formula: C₂₁H₂₄BrN₅O

InChI: InChI=1S/C21H24BrN5O/c1-14-9-18(22)13-25-19(14)5-3-4-8-23-21-26-12-17(20(28)27-21)10-16-7-6-15(2)24-11-16/h6-7,9,11-13H,3-5,8,10H2,1-2H3,(H2,23,26,27,28)

InChI key: InChIKey=OGEAASSLWZDQBM-UHFFFAOYSA-N

SMILES: C(C=1C(=O)NC(NCCCCC2=C(C)C=C(Br)C=N2)=NC1)C=3C=CC(C)=NC3

Synonyms:

• 4(1H)-Pyrimidinone, 2-[[4-(5-bromo-3-methyl-2-pyridinyl)butyl]amino]-5-[(6-methyl-3-pyridinyl)methyl]-
• 2-[[4-(5-Bromo-3-methyl-2-pyridinyl)butyl]amino]-5-[(6-methyl-3-pyridinyl)methyl]-4(1H)-pyrimidinone
• Temelastine
• SKF 93944

Temelastine

CAS: 86181-42-2

Temelastine is a selective, competitive histamine H1-receptor antagonist which does not penetrate the central nervous system.

Formula: C₂₁H₂₄BrN₅O

Color and Shape: Solid

Molecular weight: 442.35

Ref: TM-T68527